microRNA在口腔鳞癌中的研究进展

Review on the role of microRNA in Oral squamous cell carcinoma(OSCC)

口腔鳞状细胞癌(OSCC)是口腔颌面部恶性肿瘤中最主要的一类,约占80%以上,好发于男性,但近年来女性的发病率也呈现逐年增加的趋势;microRNA,是一类稳定的短序列非编码RNA,其主要功能是在转录后水平参与靶基因的调控,近来研究已发现在OSCC患者中存在许多异常表达的microRNAs,而这些分子在OSAS的发生发展中扮演着重要的角色,异常的microRNA同样对OSCC的临床诊断、治疗以及判断预后都有着重要的作用;本文对当前microRNA在OSCC中的的异常表达、作用机制以及作为诊断标记物、治疗靶点的潜能进行了综述。

Oral squamous cell carcinoma （OSCC） is one of the most common cancers worldwide about 80%, and it primarily affected male population, but the incidence of OSCC in women was increased recently. MicroRNAs （miRNAs） are small noncoding RNAs that post-transcriptionally modulate gene expression by degrading or repressing the translation of target messenger RNAs （mRNA）. Aberrant miRNA expression has been reported in OSCC, and this altered expression may be useful for the early detection of oral cancer. In this review we highlight the miRNAs profile of OSCC, mechanisms, and the potential of being diagnostic markers or therapeutic targets in OSAS.