肺炎支原体实验室检测方法研究进展

Advances in Laboratory Detection of Mycoplasma Pneumoniae

肺炎支原体(Mycoplosma pneumonia,MP)为人类非典型肺炎的病原体,是引起呼吸道感染的重要病原体。但是支原体肺炎与其他病原体感染的肺炎,在临床症状、影像学上并无特异性差别,且其对一般治疗肺炎、上呼吸道感染的药物有耐药性,因此肺炎支原体及时、准确的实验室检测对于支原体肺炎的诊断治疗显得尤为重要。目前MP的实验室检测方法不断推陈出新,但各种方法均有其优势与不足,临床可选择两种不同的方法同时检测。比如:血清学抗体的检测结合MP快速培养药敏的方法;血清学抗体的检测结合PCR的方法,不同方法相互补充为临床的早期诊断、治疗提供依据。而MP药敏试验的检测和耐药机制的研究对于临床用药方案的选择,减少耐药株的产生和流行具有重要意义。

Mycoplasma pneumoniae （MP） is a human pathogen of atypical pneumonia, is important pathogens that cause respiratory infections. Mycoplasma pneumoniae pneumonia infection with other pathogens, no specific difference in clinical symptoms and imaging, the general treatment of pneumonia and upper respiratory tract infection drug resistance. Timely, accurate laboratory detection of Mycoplasma pneumoniae is particularly important for the diagnosis and treatment of mycoplasma pneumonia. Currently the MP laboratory tests constantly, various methods have their advantages and disadvantages, clinical simultaneous detection of two different methods can be selected. For example： serological antibody detection combined the MP fast culture susceptibility method; serological antibody detection combined PCR method, different methods complement each other early clinical diagnosis, treatment, provide the basis. The MP detection and drug susceptibility testing mechanism for clinical selection regimen and reduce the generation of drug-resistant strains and popular has important significance.