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乙酰化与子宫内膜癌关系的研究进展

The Research Progress on Relationship between Acetylation and Endometrial Carcinoma
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摘要 子宫内膜癌是与代谢综合征密切相关的恶性肿瘤,蛋白质的乙酰化修饰与肿瘤和代谢疾病的发生均有密切联系。乙酰转移酶和去乙酰化酶共同维持乙酰化水平的平衡状态,一旦平衡因细胞内外环境刺激而打破,直接导致癌症(如子宫内膜癌)发生。缺乏孕激素抵抗的过量雌激素和以胰岛素抵抗为核心的代谢综合征是子宫内膜癌的两大易感因素,乙酰化修饰对二者的影响,间接引起子宫内膜癌发生。 Endometrial carcinoma is a malignant cancer which is closelyassociatedwiththemetabolic syndrome （MS）, while theacetylation modification ofsome proteins may result incancers andmetabolicdiseases. Histone acetyltransferases and deacetylasesjoint- lymaintaintheequilibriumof acetylationlevels. Oncethebalanceisbroken, due tostimulationsfromintracellular or extracellularenvironments, cancers （such as endometrial carcinoma）occur. Theexcessestrogen without resistance of progesterone,andinsulin resistance--which is the coreof themetabolicsyndrome, aretwopredisposing factorsforendometrial carcinoma. And the acetylationofthe two factors couldindirect- cause endometrial cancer.
作者 宁程程 单伟伟 张箴波 陈晓军 丰有吉
机构地区 复旦大学附属妇产科医院 上海交通大学附属第一人民医院妇产科
出处 《现代生物医学进展》 CAS 2014年第16期3194-3197,共4页 Progress in Modern Biomedicine
关键词 乙酰化 子宫内膜癌 胰岛素抵抗 去乙酰化酶抑制剂 Acetylation Endometrial carcinoma Insulin resistance HDACi
分类号 R737.33 [医药卫生—肿瘤]
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参考文献31

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二级参考文献16

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现代生物医学进展
2014年 第16期

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