青年卒中后抑郁/焦虑危险因素logistic回归分析

Logistic Regression Analysis of the Risk Factors of Post-stroke Depression and Anxiety in Young Adult Stroke Patients

目的：探讨青年卒中患者抑郁／焦虑发生的危险因素，为制定科学的管理策略提供依据。方法：选择2012年7月至2013年7月我院收治的69例青年卒中患者，采用（（Hamilton抑郁量表（HAMD）》和（（Hamilton焦虑量表（HAMA）》筛选出抑郁／焦虑病例作为病例组，其他病例作为对照组，通过多因素非条件Logistic回归模型分析青年卒中后抑郁／焦虑产生的危险因素。结果：69例青年卒中病人中，抑郁、焦虑的发生率分别约26．0％和36．2％。多因素Logistic回归分析显示NIHSS评分（OR值5．002，95％CI为4．015-6．023）、幕下病变（OR值0．466，95％CI为0．145～1．505）、伴随基础疾病（OR值0．093，95％CI为0．008-1．129）是青年卒中后抑郁／焦虑出现的危险因素。结论：对青年卒中患者要积极控制基础疾病，重视幕下病变和严重残疾，有助于预防及早期识别卒中后抑郁／焦虑的产生。

Objective： To explore the risk factors of depression and anxiety following stroke in young adults and provide evidenc- es for the management. Methods： 69 cases of stroke in young adults hospitalized from July 2012 to July 2013 were included in our study, all of them were screened for Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale （HAMA）. Patients with depression/ anxiety were selected as the case group, the others were used as the control group, multivariate conditional Logistic regression was performed to analyze the risk factors ofpoststroke depression/anxiety in young adults. Results： 18（26%） patients suffered from depressi- on and the incidence of anxiety was 36.2 % （25/69）. Logistic regression analysis showed that NIHSS score （OR value 5.002, 95% CI 4.015 -6.023）, infratentorial lesions （OR value 0.466, 95% CI 0.145-1.505）, underlying diseases （OR value 0.093, 95% CI the 0.008-1.129） were correlated with the occurrence of post-stroke depression and anxiety. Conclusion： Active treatment of underlying diseases, focus on the infratentorial lesions and severe disability, could contribute to the prevention and early identification of post-stroke depression / anxiety in young adult stroke patients.