期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Eph-Ephrin双向信号转导途径在眼部血管新生中的作用 被引量：2

Bidirectional Signaling Mechanism of Eph-Ephrin in Ocular Angiogenesis
原文传递
导出
摘要 Eph/Ephrin家族是受体酪氨酸激酶家族中的最大亚族,在生理和病理性血管形成中起重要作用。眼部血管生成是糖尿病视网膜病、早产儿视网膜等眼部疾病致盲的重要因素,Eph和Ephrin基因在上述眼部疾病中有不同程度表达改变。Eph受体及其配体Ephrin之间的双向信号机制是Eph-Ephrin发挥功能的主要方式。本文就Eph-Ephrin双向信号机制在眼部血管新生中的作用进行综述。 Eph/Ephrin, the largest subfamily of receptor tyrosine kinases （RTKs）, plays an important role in both physiological and pathological angiogenesis. Ocular angiogenesis is an important pathological phenomenon of some ocular disorders such as diabetic retinopathy and retinopathy of prematurity, which may result in blindness. It has been reported that there are alteration of Eph and Ephrin expression in ocular angiogenesis-related disorders, suggesting that Eph-Ephrin maybe play roles in ocular angiogenesis. Eph-Ephrin exerts their roles by the bidirectional signaling between Eph receptor and Ephrin ligand. This review focused on the roles of bidirectional signaling of Eph-Ephrin in ocular angiogenesis.
作者 周婷 贾素洁 江俊麟
机构地区 中南大学药学院药理学系 中南大学湘雅三医院药剂科
出处 《现代生物医学进展》 CAS 2014年第17期3365-3368,共4页 Progress in Modern Biomedicine
基金 国家自然科学基金项目(81373408)
关键词 EPH受体 Ephrin配体 血管新生 Eph receptor Ephrin ligand Angiogenesis
分类号 R77 [医药卫生—眼科]
  • 相关文献

参考文献35

  • 1Wang B. Cancer cells exploit the Eph-ephrin systemto promote invasionand metastasis: tales of unwitting partners [J]. Sci Signal, 2011, 4(175): pe28.
  • 2Willard AL Herman IM. Vascular complications and diabetes: currenttherapies and future challenges [J]. J Ophthalmol, 2012, 2012: 209538.
  • 3Pasquale EB. Eph-ephrin bidirectional signaling in physiology anddisease [J]. Cell, 2008, 133(1): 38-52.
  • 4Klein R. Bidirectional modulation of synaptic functions by Eph/ephrinsignaling [J]. Nature, 2009, 12(1): 15-20.
  • 5Pasquale EB. Eph receptors and ephrins in cancer: bidirectionalsignalling and beyond [J]. Nature, 2010, 10(3): 165-180.
  • 6Cowan CA, Henkemeyer M. The SH2/SH3 adaptor Grb4 transducesB-ephrin reverse signals [J]. Nature, 2001, 413(6852): 174-179.
  • 7Hoogenraad CC, Milstein AD, Ethell IM, et al. GRIP1 controlsdendrite morphogenesis by regulating EphB receptor trafficking [J].Nat Neurosci, 2005, 8(7): 906-915.
  • 8Zhang J, Hughes S. Role of the ephrin and Eph receptor tyrosinekinase families in angiogenesis and development of the cardiovascularsystem[J]. J Pathol, 2006, 208(4): 453-461.
  • 9Wang Y, Nakayama M, Pitulescu ME, et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis [J]. Nature, 2010, 465(7297): 483-486.
  • 10Herbert SP, Huisken J, Kim TN, et al. Arterial-venous segregation byselective cell sprouting: an alternative mode of blood vesselformation [J]. Science, 2009, 326(5950): 294-298.

同被引文献23

  • 1Nusslein VC, Wieschaus E. Mutations affecting se~nent numberand polarity in Drosophila[J]. Nature, 1980,287(5785) :795-801.
  • 2Merchant AA, Matsui W. Targeting Hedgehog-a cancer stem cell pathway[J]. Clin Cancer Res, 2010,16(12) : 3130-3140.
  • 3Qing X, Ning H, Pan H. Impaired 1 sonic hedgehog pathway con- tributes to cardiac dysfunction in type 1 diabetic mice with myocar- dial infarction[ J]. Car Res,2012(95 ) :507-516.
  • 4Hong KD, Lee Y, Kim BH, et al. Expression of GLI1 correlates with expression of lymphangiogenesis proteins, vascular endothelial growth factor C and vascular endothelial growth factor receptor 3, in coloreetal cancer[ J ]. Am Surg,2013,79 (2) : 198-204.
  • 5Liu H, Zhang W, Kennard S, et al. Notch3 is critical for proper angiogenesis and mural cell investment [J]. Circ Res, 2010,10 (7) :860-870.
  • 6Lawson ND, Vogel AM,Weinstein BM, et al. Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch path-way during arterial endothelial differentiation[ Jl. Dev Cell, 2002, 17(3) :127-136.
  • 7Wang LC,Liu ZY, Gambardella L, et al. Conditional disruption of hedgehog signaling pathway defines its critical role in hair develop- ment and regeneration [ J ]. Invest Dermatol, 2000,11 ( 4 ) :901-908.
  • 8van Tuyl M, Groenman F, Wang J, et al. Angiogenic factors stim- ulate tubular branching morphogenesis of sonic hedgehog-deficient lungs[J]. Dev Bio, 2007,30 (3) :514-526.
  • 9Ola MS, Nawaz MI, Siddiquei MM, et al. Recent advances in un- derstanding the biochemical and molecular mechanism of diabetic retinopathy [J]. J Diabet Its Compli,2012,26( 1 ) :56-64.
  • 10Chen J, Hicks D, Brantley-Sieders D, et al. Inhibition of retinal neovascularization by soluble EphA2 receptor [ J ]. Exp Eye Res, 2006,82(4) : 664-673.

引证文献2

二级引证文献4

现代生物医学进展
2014年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部