NNMT蛋白酶与肿瘤的关系

The Relationship between NNMT and Tumours

尼克酰胺甲基转移酶(NNMT,E.C.2.1.1.1),一种参与物质代谢的酶蛋白,在肝脏的解毒和物质代谢过程中起重要作用。随着蛋白质组学的发展,人们运用2-DE,蛋白微阵列,基因芯片等技术发现NNMT在很多肿瘤中都是一个高表达蛋白质,它与肿瘤的关系也得到了研究者们进一步的证实,并提示NNMT与多种肿瘤的发生发展和转移相关,可作为一些肿瘤如肺小细胞肺癌、肾癌、口腔鳞状细胞癌和膀胱癌等的早期诊断和预后的标记物。本文就NNMT与肿瘤的关系及相关信号通路做一综述。

Nicotinamide N-methytransferase （NNMT, E.C.2.1.1.1）, an enzyme involved in drug metabolism, plays a critical role in detoxify in liver and substance metabolism. NNMT was found overexpressed in many tumaours through 2-DE, protein microarrays, gen chips along with the develop of proteomics, the relationship with tumours were confirmed by researchers and suggested NNMT engagement in the development and metastasis in various of cancers, hence, NNMT can act as a diagnosis and prognosis biomarker of some cancers such as non-small cell lung cancer, renal cancer, renal cancer, oral squamous cell carcinoma, and bladder cancer. This text is aimed at the correlation of NNMT and tumours and relevance signal pathways.