肝郁血虚型慢性荨麻疹患者负性情绪对神经生长因子和P物质水平的影响

Effects of Negative Emotions on Levels of Nerve Growth Factor and Substance P in Depressed Liver and Blood Deficiency Type of Chronic Urticaria

目的:探讨肝郁血虚型慢性荨麻疹(CU)患者焦虑负性情绪与血清神经生长因子(NGF)和P物质(SP)水平的关系。方法:应用汉密顿焦虑量表(HAMA)对肝郁血虚型CU患者进行评分,评价患者的焦虑程度,应用双抗体夹心法测定患者血清中NGF和SP水平,与正常组作比较。结果:肝郁血虚型CU组HAMA评分高于正常组,可能对血清NGF和SP水平有影响。结论:肝郁血虚型CU患者焦虑负性情绪对病情影响与血清NGF和SP水平变化可能有关联。

Objective：To investigate the relation of anxiety, nerve growth factor （NGF） and substance P （SP） in de- pressed liver and blood deficiency type of chronic urticaria （CU）. Methods：The patients＇ mood was measured with Hamilton Anxiety Scale （ HAMA ）. The serum levels of NGF and SP were determined by double antibody sandwich method as compared with those of the normal group. Results ： The HAMA scores of depressed liver and blood deficiency type of CU group were higher than that in normal group and can influence the serum levels of NGF and SP. Conclusion：Anxiety may play an important role in the occurrence of depressed liver and blood deficiency type of CU through NGF and SP.