祛湿化瘀方对非酒精性脂肪肝患者脂质代谢、肝功能及肝纤维化的影响

Effect of Qushi Huayu Decoction on Lipid Metabolism,Liver Function and Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

目的:探讨祛湿化瘀方治疗非酒精性脂肪性肝病(NAFLD)的疗效及其对NAFLD患者血脂、肝功能及肝纤维化的影响。方法:80例NAFLD患者随机分为两组(各40例),对照组予常规治疗,观察组加用祛湿化瘀方口服,疗程3个月。在治疗前后分别行血脂(TC、TG)、肝功能(ALT、AST)及肝纤维化指标(HA、LN、PCⅢ、CⅣ)水平检测。结果:治疗后两组血脂、肝功能、肝纤维化指标均较治疗前降低(P<0.05),且观察组ALT、AST、HA、LN、PCⅢ、CⅣ改善程度明显优于对照组(P<0.05)。观察组治愈率、显效率和有效率分别为10%、55%、35%,而对照组为2.5%、32.5%和45%,观察组疗效优于对照组(P<0.05)。结论:祛湿化瘀方明显改善NAFLD患者肝功能和肝纤维化程度,能有效治疗NAFLD。

Objective ： To explore the effect of Qushi Huayu Decoction （QSHYD） on liver function and liver fibrosis, and its efficacy on treatment of non -alcoholic fatty liver disease （NAFLD）. Methods： 80 cases of NAFLD patients were randomly divided into two groups （40 cases in each group）. Patients in control group were given conventional treatment and patients in observation group given QSHYD additionally, both were treated for 3 months. Levels of lipids （TC ,TG）, liver function （ ALT, AST） and liver fibrosis indexes （ HA, LN, PCIII, CIV） were detected before and after treatment. Results： After treatment, the levels of lipid, liver function and hepatic fibrosis indexes in both groups were lower than those before therapy （ P 〈 0.05 ）, and the levels of ALT, AST, HA, LN, PCIII and CIV of observation group were improved significantly better than those in control group （ P 〈 0.05 ）. The cure, excellence and effective rates of in observation group were 10% ,55% ,35% and those were 2.5% ,32.5% and 45% in control group, and the curative effect of observation group was better than that of control group （P 〈 0.05 ）. Conclusion： QSHYD can improve liver function and the degree of liver fibrosis in patients with NAFLD and it is effective in the treatment of NAFLD.