前瞻性临床随机对照研究艾夫吉夫对具有感染高危因素剖宫产切口愈合的影响

Prospective randomized controlled clinical trial of rhaFGF on cure of cesarean incision on patients with highly infective risk factors

目的观察艾夫吉夫对具有感染高危因素的剖宫产妇女术后切口愈合的影响。方法选择2011年5月～2013年5月在我院妇产科进行剖宫产手术并具有切口感染高危因素的待产孕妇167例，随机分为治疗组和对照组．对照组皮层缝合前采用生理盐水清洗创口，治疗组采用艾夫吉夫（rhaFGF）清洗，皮肤缝合后于创面喷雾rhaFGF。术后随访观察切口愈合时间、延迟愈合人数，记录产妇住院时间、术后感染发生以及抗生素使用情况。结果治疗组与对照组相比，在平均愈合时间[（8．1±2．8）vs（13．1±4．7），P=0．032]、延迟愈合情况（29．1％vs4．9％，P=0．013）、切口感染情况（6．2％vs37．2，P=0．006）、瘢痕平均直径[（7．6±1．9）vs（13．0±2．1），P=0．045）]，术后并发症以及抗生素使用情况比较，差异均有统计学意义（P〈0.05）。结论艾夫吉夫对剖宫产妇女术后切口愈合、减少感染发生具有积极的作用。

Objective To investigate the effect of rhaFGF on cure of cesarean incision on patients with highly infective risk factors. Methods 167 cesarean section patients with highly infective risk factors were observed in our hospital maternity from May 2011 to May 2013. These cases were randomly prospective divided into treatment group（n=81 ,treated with rhaFGF washing during operation）and control group （n =86,treated with saline washing during operation ） .The wound healing time ,in-hospital days, number of delayed healing, postoperative infection, and application of antibiotics were recorded during the follow-up. Results Statistical analysis showed that, the healing time[（8.1 ±2.8）vs （13.1± 4.7）, P=0.032], delayed healing （29.1% vs 4.9%, P=0.013 ）, wound infection （6.2% vs 37.2, P=0.006）, scar diameter [（7.6±1.9）vs （13.0±2.1）,P=0.045）], postoperative complications and the application of antibiotics in the treatment group were better than those in the control group （P〈0.05）. Conclusion Rha-FGF Showed positive influence on the preventing cesarean section wound bad healing.