血小板相关指标和凝血功能检测对慢性肝病治疗意义的探讨

Discussion of parameters of platelet and blood coagulation for the treatment of chronic liver diseases

目的研究慢性肝病患者血小板计数相关指标和凝血功能试验结果在各期肝炎病情中的变化,监测患者的肝损程度。方法 85例健康体检者为对照组,276例慢性肝病患者为观察组,用血液分析仪测定血小板计数(PLT)、血小板压积(PCT)、血小板平均体积(MPV)、血小板分布宽度(PDW)、大血小板比率(P-LCR)水平;用血凝仪测定凝血酶时间(TT)、凝血酶原时间(PT)、凝血酶原时间国际标准比值(PT-INR)、部分活化凝血活酶时间(APTT)、纤维蛋白原(FIB)浓度。结果慢性肝炎、肝硬化、重症肝炎、肝癌组MPV、P-LCR、TT、PT、PT-INR、APTT测定值均高于对照组;PLT、PCT、FIB测定值低于对照组;PDW均值增大,表明患者血小板体积不均一性增大。结论血小板计数相关指标和凝血功能检测可作为监测慢性肝病患者病情进展及严重程度的重要指标。

Objective To investigate the parameters of platelet and blood coagulation in patients with chronic liver disease in each period,monitoring liver damage degree of patients. Methods Eighity-five healthy cases were chose as controls,while 276 patients with chronic liver disease as the observers. The levels of platelet （PLT）,thrombocytocrit （PCT） ,mean platelet volume （MPV） and platelet distribution width （PDW）,the ratio of large platelet （P - the LCR） were detected by the blood analyzer; Blood coagulation analyzer was used to detect thrombin time （TT）, prothrombin time （PT）, prothrombin time （PT - INR）, activated partial thromboplastin time （APTT）, fibrinogen （FIB）. Results The level of MPV,P-LCR,TT,PT,PT INR and APTT were higher in chronic hepatitis, cirrhosis, severe hepatitis and hepatocellular carcinoma compared to controls （P〈0.05） whereas PLT, PCT and FIB were lower （P 〈 0.05）; The increased of PDW promoted the distribution curve changed. Conclusion The parameters of platelet and blood coagulation can be used as an important biomarkers in the progression of patients with chronic liver diseases.