摘要
目的:探讨 L-selectin(L-选择素)和 ICAM-1(细胞间粘附分子-1)在乙型肝炎病毒感染造成肝功能损害过程中的作用。方法:定量检测42例乙型肝炎病人血清 HBV DNA 拷贝数、可溶性 L-选择素(sL-selectin)、可溶性细胞粘附分子-1(sICAM-1)及肝功能相关生化指标,并对结果进行统计分析。结果:22例 DNA 阴性和20例 DNA 阳性病人血清 sL-selectin 和 sICAM-1水平均明显高于对照组(P<0.05),但 DNA 阴性组和阳性组之间的 sL-selectin 和 sICAM-1水平均无显著差异(P>0.05);DNA 拷贝数与 sICAM-1水平呈负相关(r=-0.501,P<0.05);DNA 拷贝数与肝功能损害呈负相关;42例乙肝病人的 sL-selectin 和 sICAM-1水平均与肝功能损害呈不同程度的正相关。结论:L-selectin 和 ICAM-1均参与乙肝病毒感染后的肝功能损害过程,而血清中 sL-selectin 水平升高要早于 sICAM-1。
Objective:To evaluate the effect of L-selectin and ICAM-1 in the liver injury of the pa-tients infected with hepatitis B virus(HBV).Methods:We measured the copys of HBV DNA,thelevels of sL-selectin,sICAM-1 and chemical markers in the patients infected with HBV and evaluatedtheir relationships each other.Results:A significant elevations of sL-selectin and sICAM-1 levels wereobserved in 42 cases of patients infected with HBV,including 22 cases of HBV DNA negative patientsand 20 cases of HBV DNA positive patients(P<0.05),but no significant difference of the levels ofsL-selectin and sICAM-1 between the patients with HBV DNA negative and HBV DNA positive(P>0.05);there was a negative correlation between the copys of HBV DNA and sICAM-1(r=-0.501,P<0.05);there was a negative correlation between the copys of HBV DNA and the chemical markers ofthe liver injury;there were positive correlations with different degrees between both the sL-selectin andsICAM-1 levels and the liver injury in the 42 cases of patients.Conclusion:Both L-selectin and ICAM-1 play an important role in the liver injury in the patients infected HBV.The sL-selectin level rose earlierthan the sICAM-1 level in the patients.
