幽门螺杆菌感染与IgA肾病的发生与发展

Helicobacter pylori infection and the development and progression of IgA nephropathy

IgA肾病是全球范围内最为常见的原发性肾小球疾病,目前公认其是一种免疫介导性炎症疾病,但具体发病机制尚不清楚。幽门螺杆菌(Hp)是一种定植于人类胃肠道的微需氧革兰阴性菌,幽门螺杆菌感染能引起急慢性的炎症免疫反应。近年来研究发现Hp感染与IgA肾病之间存在一定的联系,Hp可能是IgA肾病的潜在致病原之一。相关研究已成为目前学术界的热点。该文结合国内外和四川大学生物治疗国家重点实验室团队的研究,就HP感染与IgA肾病的发生发展机制进行了论述。

IgAnephropathyisthemostcommonprimaryglomerulardiseaseworldwidewhichis recognized as a kind of immune-mediated inflammatory disease although its pathogenesis is not clear yet. Helicobacter pylori（ Hp ） is a kind of microaerobic gram-negative bacterium colonized in human gastrointestinal tract. Hp infection can cause acute or chronic immune inflammation. In recent years,it has been found that there is a certain relationship between Hp infection and IgA nephropathy,and that Hp is likely to be one of the potential pathogenic agents of IgA nephropathy,and related research has become a hot spot of academia. Whether Hp infection is associated with the development and progression of IgA nephropathy has become a hot spot of research. This review will discuss HP infection and pathological mechanism of IgA nephropathy,synthesizing domestic and international results including our own.