多枝柽柳中的酚酸类化学成分

Phenolic compounds in branches of Tamarix rasissima

多枝柽柳在宁夏民间常用于治疗类风湿关节炎,为了寻找其中的有效成分,为药用开发提供科学依据,对多枝柽柳的化学成分进行了研究。利用硅胶柱色谱、凝胶柱色谱和重结晶法对多枝柽柳的化学成分进行分离纯化,化合物的结构依据其理化性质和波谱数据得以鉴定。从正丁醇层中分离得到10个化合物,分别鉴定为monodecarboxyellagic acid(1),鞣花酸(2),3,3'-二甲基鞣花酸(3),3,3'-二甲基鞣花酸-4-O-β-D-葡萄糖苷(4),3,3'-二甲基鞣花酸-4'-O-α-D-阿拉伯糖苷(5),阿魏酸(6),异阿魏酸(7),咖啡酸(8),4-氧-乙酰基咖啡酸(9),4-甲基-1,2-二苯酚(10)。除化合物7异阿魏酸外,其余9个化合物均为首次从该植物中分离得到,其中5,9,10为首次从该属植物中分离得到。

To study the chemical constituents of the branches of Tamarix rasissima, repeated silica gel column chromatography, Sephadex LH-20 chromatography and recrystallization were applied for chemical constituents isolation and purification.Ten phenolic compounds were isolated from the n-BuOH fraction and their structures were elucidated by physical properties and spectra analysis such as UV, ESI-MS and NMR as monodecarboxyellagic acid （1）,ellagic acid （2）,3, 3′-di-O-methylellagic acid （3）,3, 3′-di-O-methylellagic acid-4-O-β-D-glucopyranoside （4）,3, 3＇-di-O-methylellagic acid-4＇-O-α-D-arabinfuranoside （5）,ferulic acid （6）,isoferulic acid （7）,caffeic acid （8）,4-O-acetyl-caffeic acid （9）,and 4-methyl-1,2-benzenediol （10）.All compounds except for isoferulic acid were isolated firstly from this plant except for isoferulic acid, and compounds 5,9 and 10 were obtained from Tamarix genus for the first time.