D-二聚体、NT—proBNP水平改变在急性冠脉综合症病变患者中的临床意义

Analysis on clinical significance of D-dimer, NT-proBNP levels change in patients with acute coronary syndrome lesions

目的探讨D-二聚体、N末端脑钠肽前体（NT—proBNP）水平改变在急性冠脉综合征（ACS）患者中的临床意义。方法选取我院收治的46例ACS患者作为观察组，同期46例健康体检者作为对照组，均抽取静脉血行常规检查和血浆D-二聚体、NT—proBNP检测。比较两组血浆D-二聚体、NT—proBNP水平。结果观察组血浆D-二聚体水平为（2．28±0．21）mg／L，显著高于对照组的（0．24±0．09）mg／L（P〈0．05）；观察组血浆NT—proBNP水平为（537．13±197．28）μg／L，显著高于对照组的（66．54±23．35）μg／L（P〈0．05）。结论血浆D-二聚体和NT—proBNP水平同急性冠脉综合征的发生密切相关，联合检测血浆D-二聚体和NT—proBNP水平可有效提高ACS的检出率，对早期诊断和早期治疗具有重要的临床意义。

Objective To investigate the clinical significance of D-dimer, N-terminal brain natriuretic peptide （NT-proBNP） levels change in patients with acute coronary syndrome （ACS） lesions. Methods 46 cases of ACS in our hospital were selected as the observation group. Other 46 healthy people in same period were chosen as the control group. Blood samples of two groups were taken for routine inspection and plasma D-dimer, NT- proBNP testing. The levels of D-dimer and NT-proBNP of two groups were compared. Results The plasma D-dimer and NT-proBNP levels of observation group were （2.28 ± 0.21） mg/L and （537.13 ±197.28） μ g/L respectively, which were significantly higher than those of control group： （0.24 ± 0.09） mg/L and （66.54± 23.35） μ g/L （P 〈 0.05）. Conclusions Plasma D-dimer and NT-proBNP levels are closely related to acute coronary syndrome. The combined detection of plasma D-dimer and NT-proBNP levels can effectively improve the detection rate of ACS. It has important clinical significance to early diagnosis and early treatment.