摘要
合成了 12个水杨酰苯胺类化合物及类似物 ,对目标化合物进行了初步的活性筛选 ,发现部分化合物具有一定的抗炎、抗变态反应活性 ,其中N (3 硝基 4 乙氧基苯基 ) 2 羟基苯甲酰胺对2 ,4 二硝基氯苯诱导的小鼠迟发性变态反应的抑制作用与乙氧苯柳胺相近 .
Twelve compounds of salicylanilide and its analogues were synthesized and screened for bioactivities.Preliminary pharmacological tests showed that some target compounds possessed antiinflammatory and(or)antiallergic activities. N (4 Ethoxy 3 nitrophenyl) 2 hydroxybenzamide showed similar inhibitory effect to that of etofesalamide on DNCB induced allergy in mice.
出处
《中国药物化学杂志》
CAS
CSCD
2000年第4期250-253,共4页
Chinese Journal of Medicinal Chemistry