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N-苄氧羰基-S-苯基-L-半胱氨酸的合成 被引量：1

Synthesis of N-Benzyloxycarbonyl-S-phenyl-L-cysteine
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摘要 以半胱氨酸为原料经重氮化 ,酰化反应合成了N 苄氧羰基 S 苯基 L 半胱氨酸 . N benzoxycarbonyl S phenyl L cysteine,as an important intermediate for producing Nelfinavir was synthesized with L cysteine as the starting material.The process is convenient and the yield is higher.
作者 王建武 赵永华 王彤
机构地区 山东大学化学与环境科学学院
出处 《中国药物化学杂志》 CAS CSCD 2000年第4期283-284,共2页 Chinese Journal of Medicinal Chemistry
关键词 N-苄氧羰基-S-苯基 半胱氨酸 重氮化 酰化 合成 N Cbz S phenyl cysteine synthesis diazotization acylation
分类号 R914 [医药卫生—药物化学]
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参考文献2

  • 1Gifford M,Stephen WK,Anthony JT,Brian MS,et al.A convenient large scale synthesis of N-Cbz-( S-phenyl)-Lcysteine[].Synthetic Communications.1995
  • 2Saul W,Peter MK,Hillar A.Cyclization of cysteinylglycine sulfoxides under Pummerer reaction conditions[].Canadian Journal of Chemistry.1979

同被引文献13

  • 1王娟娟,汪明芳,张关永.S-苯基-L-半胱氨酸合成的反应动力学及反应机理的研究[J].化学世界,2007,48(5):257-261. 被引量：2
  • 2Maier T H. Semisynthetic production of unnatural L-a-amino acidsby metabolic engineering of the cysteine biosynthetic pathway[J].Nature Biotechnology,2003,21(4) :422 -427.
  • 3Thomas M,Carsten G. Process for the production of non-proteinogenic amino acids [P]. EP1247869A1,2002.
  • 4Miles,Edith Wilson. The tryptophan synthase a2b2 complex:amodel for substrate channeling, allosteric communication, andpyridoxal phosphate catalysis [J]. Journal of Biological Chemistry,2013,288(14) :10084 - 10091.
  • 5Axe Jennifer M,Boehr David D. Long-range interactions in thealpha subunit of tryptophan synthase help to coordinate coordinateligand binding, catalysis, and substrate channeling [J]. Journal ofMolecular Biology,2013,425(9) : 1527 - 1545.
  • 6Behera Santosh Kumar,Panda Amrita,Bisht,Satpal Singh.Comparative genomics of 芦-subunit of Tryptophan synthase among agroup of proteobacteria[J]. Bioinformatics Trends,2011,6(3/4):16 - 21.
  • 7Evran Serap,Telefoncu Azmi,Sterner Reinhard. Directedevolution of ( ba ) 8-barrel enzymes : establishingphosphoribosylanthranilate isomerization activity on the scaffold ofthe tryptophan synthase a-subunit [J]. Protein Engineering,Design & Selection,2012,25(6) :285 -293.
  • 8Kazuya N,Kyoko 0,Yukio M,et al. Large conformational changesin the Escherichia coli tryptophan synthase /32 subunit uponpyridoxal 5,-phosphate binding [J]. FEBS Journal, 2010,277(9):2157 -2170.
  • 9Dierkers AT,Dimitri N,lime S,ei al. Tryptophan synthase:structure and function of the monovalent cation site [J].Biochemistry ,2009,48 (46) : 10997 - 11010.
  • 10Lai JF,Dimitri N,Wang YC,et al. X-ray and NMRcrystallography in an enzyme active site: the indoline quinonoidintermediate in tryptophan synthase [J]. J Am Chem Soc,2011,133(1):4-7.

引证文献1

中国药物化学杂志
2000年 第4期

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