青霉烯类酶抑制剂的研究进展

Research Development in the β-Lactamase Inhibitor of Penem

细菌的耐药性迫切需要新的酶抑制剂的出现 .亚甲基青霉烯是一类新的 β 内酰胺酶抑制剂 .本文综述了其构效与抑酶活性的关系 .寻求抑酶活性更高、药理特性好及临床效果更好的青霉烯类的酶抑制剂仍为今后研究的方向 .

This review offers an overview of the β lactamase inhibitor of penem.Methylene penem is the new β lactamase inhibitor.Its structure activity relationship has already been studied broadly.The development challeges researchers to seek for the β lactamase inhibitor with high inhibitory activity,good pharmacological action and clinical effects.