丹参多酚对慢性阻塞性肺疾病急性加重期肺动脉压及D-二聚体的影响

Influence of salvianolate on AECOPD pulmonary artery pressure and D-dimer

目的:探讨丹参多酚注射液对慢性阻塞性肺疾病急性加重期肺动脉压及D-二聚体的影响。方法:40例符合诊断标准的AECOPD患者被随机分为对照组和治疗组,两组均接受COPD诊治指南推荐的抗感染、化痰、平喘、吸氧等治疗,治疗组在上述治疗的基础上与丹参多酚200mg/d,静脉滴注,两组疗程均为14d,治疗前后分别测定肺动脉压及D-二聚体,对其结果进行统计学分析。结果:治疗前两组AECOPD患者D-二聚体水平均高于正常参考值上限,治疗后两组肺动脉压及D-二聚体水平均有下降,其中治疗组上述指标下降更为显著,治疗前后比较P<0.05;治疗后组间比较亦有显著性差异P<0.05。结论:丹参多酚注射液可改善AECOPD患者血液高凝状态,改善机体氧合功能,降低肺动脉压,有助于提高临床疗效。

Objective： To investigate the influence of salvianolate on COPD acute exacerbation pulmonary artery pressure and D-dimer. Methods： 40 patients with chronic obstructive pulmonary disease acute exacerbation （AECOPD） were randomly divided into control group and treated group. Both groups were accepted COPD treatment guidelines recommend anti-infection, phlegm, asthma, oxygen therapy etc. The treated group was given salvianolate 200mg/d, intravenous infusion more. The treatment lasted 14 days, before and after treatment pulmonary artery pressure and D-dimer were measured, the results were statistically analyzed. Results：Before treatment, patients with AECOPD D-dimer levels were higher than the upper limit of normal reference values, the two groups after the treatment pulmonary arterial pressure and D-dimer levels were decreased, in the treated group decreased more significantly above indicators, before and after treatment P〈0.05. Between the two groups showed significant differences P〈0.05. Conclusion：Salvianolate injection can improve AECOPD patients with hypercoagulable states, improve the body’s oxygenation and reduce pulmonary artery pressure, helps to improve the clinical efficacy.