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大黄对肠缺血再灌注致大鼠炎症反应的防治作用 被引量:23

Protective Effect of Rhubarb on Inflammation Response Induced by Intestinal Ischemia-Reperfusion in Rats
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摘要 目的 :初步探讨大黄对肠缺血再灌注 (I/R)诱发的肠粘膜屏障损伤及机体炎症反应的防治作用。方法 :将大鼠分为对照、I/R及治疗 3组 ,检测各组动物肠组织SOD、血TXA2 及内毒素水平 ,并观察细菌培养结果、脏器指标及生存率。结果 :肠I/R后肠组织内SOD耗损 ,血TXA2 水平升高并伴有严重的内毒素血症及菌血症 ;预先以大黄治疗可使肠内SOD耗损减少 ,血TXA2 水平明显下降 ,同时细菌、内毒素易位减少 ,脏器功能指标改善 ,动物致伤 2 4h生存率提高 40 %。结论 :大黄可减轻大鼠肠I/R后肠粘膜屏障破坏 。 Objective This observation was designed to explore the protective effect of rhubarb on inflammation response induced by intestinal ischemia reperfusion (I/R) in rats. Methods All rats were randomly divided into control, gut I/R and treated group.In every group,the gut O -· 2 activity, blood thromboxane A 2 (TXA 2) and endotoxin level were detected and the survival rate,organ functions were observed.Results Gut I/R increased the gut O -· 2 activity and induced endotoxemia and bacterimia.Pretreatment with rhubarb could attenuate bacterial and endotoxic translocation,lower the level of blood TXA 2 and abate the vital organs dysfunction. The 24?h survival rate increased by 40%.Conclusion Rhubarb abates the gut barrier fai^lure induced by gut I/R and protects organs from dysfunction induced by inflammation response.
出处 《南京铁道医学院学报》 2000年第4期246-248,共3页 Journal of Nanjing Railway Medical College
关键词 大黄 缺血再灌注 多器官损伤 中药 药理 rhubarb gut ischemia reperfusion multiple organ dysfunction rats
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  • 1[1]Sheng Z Y, Dong Y L, Wang X H. Bacterial translocation and multiple system organ failure in bowel ischemia and repeffusion [J].J Trauma,1992,32(2):148-53.
  • 2[2]Berg R D, Garlington A W. Translocation of certation of certain indigenous bacteria from the gastrointestinal tract to the MLN and other organs in a gnotobiotc mouse model[J]. Infect Immun,1979,23:403-11.
  • 3[3]Parks D A, Granger D N. Contributions of ischemia and repeffusion to mucosal lesion formation[J]. Am J Physiol,1986,250(6):G749-53.
  • 4陈德昌,景炳文.大黄对肠源性感染治疗作用的实验研究[J].中国急救医学,1993,13(5):7-9. 被引量:45

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