旁氏无暇透白日霜改善黄褐斑及其皮肤屏障功能的疗效观察

Clinical observation on the curative effects of POND'S Ultra Luminous Day Cream in improving symptoms and skin barrier function of patients with melasma

目的观察旁氏无暇透白日霜(SPF 15 PA++)改善黄褐斑临床症状及皮肤屏障功能的疗效。方法采用随机双盲、自身对照的临床研究方法。选取30例面部皮损较对称的黄褐斑患者,受试者每天用温水清洁面部,半脸使用约0.5g测试产品,另外半脸使用等量对照产品,早晚各1次,2次/d。分别于首诊、治疗后第28天、56天评估皮损情况。结果①主观比较:实验组基本治愈0例,显效4例,好转10例,无效16例,总有效率46.6%。对照组基本治愈0例,显效1例,好转5例,无效24例,总有效率20.0%。治疗组与对照组疗效经卡方检验差异有统计学意义(P<0.05)。②TEWL值:试验组与对照组随时间延长TEWL值均值均有所降低,治疗组与对照组相比0、28、56天P值均>0.05,差异无统计学意义。③皮肤角质层含水量:试验组与对照组随时间延长皮肤角质层含水量均值均有所升高,治疗组与对照组相比0、28天P值均>0.05,差异无统计学意义,第56天时,试验组角质层含水量(41.14±5.94)与对照组角质层含水量(41.90±5.81)比较,差异有统计学意义(P<0.05)。④LAB值检测:随时间延长实验组与对照组LabL值均值均有所升高、LabA值均值无明显变化、LabB值均值均有所下降。实验组与对照组相比,LabL值0、28天P值均>0.05,差异无统计学意义;56天时,实验组LabL值(58.92±3.52)与对照组LabL值(56.86±3.11)相比,差异有统计学意义(P<0.05)。LabA值0、28、56天P值均>0.05,差异无统计学意义。LabB值0、28天P值均>0.05,差异无统计学意义;56天时,实验组LabB值(15.21±1.90)与对照组LabB值(16.16±1.52)相比,差异有统计学意义(P<0.05)。结论受试品"旁氏无暇透白日霜"和对照品市售"凡士林保湿露"均具有良好的美白、保湿、恢复皮肤屏障的效果,并且"旁氏无暇透白日霜"美白效果显著优于对照品市售"凡士林保湿露"。

Objective To observe the curative effects of POND＇S ultra luminous day cream （SPF15/ PA ± ±, POND＇S in brief） in improving the symptoms and barrier function of patients with melasma. Methods 30 patients of melasma with balanced facial skin lesion were selected in the clinical observation. The patients wash their faces with warm water in the morning and night every day, then topically apply about 0.5g sample of POND＇S on one half of the face and the same quality of control substance, which is Vaseline moisturizing lotion made by Unilever company, on another half of the face simultaneously. The lesions were observed and evaluated at the first, the 28th and the 56th day respectively through randomized double-blind, self-control clinical researching method. Results ① 4 cases had marked effect, 10 cases were improved, 16 had no effect in treatment group, the total effective rate of which was 46.6%. 1 case had marked effect, 5 cases were improved, 24 cases had no effect in control group, the total effective rate of which was 20%. The difference of the curative effect in two groups was statistically significant （P〈0.05）. ②The TEWL mean values of treatment group and control group are both reduced in time -development manner, but there have no significant difference （ P〉0.05 ）. ③ The mean values of water content in stratum corneum in both groups are raised in time-development manner, but have no significant difference at the 1st and the 28th day （P〉 0.05）. At the 56th day, the water content in stratum corneum of treatment group （41.14±5.94） is lower than that of control group （41.90±5.81） （P〈0.05）. ④ The mean LabL values of both groups are raised, the mean LabA values have no significant change, while the mean LabB values are reduced. The treatment group compared with control group, LabL value at 0, 28 days （ P〉0.05 ）, there was no statistically significant difference ; the experimental group LabL value （58.92 ± 3.52） compared with control group LabL value （56.86-3.11） at 56 days, the difference was statistically significant （P〈 0. 05）. LabA value at 0, 28, 56 days （P〉0.05）, there was no statistically significant difference. LabB value at 0,28 days （P〉0. 05 ）, there was no statistically significant difference; the experimental group LabB value （15.21±1.90） compared with control group LabB value （16.16-1.52） at 56 days, the difference was statistically significant （P〈0.05）. Conclusion Both the sample of POND＇S ultra luminous day cream and the control substance of Vaseline moisturizing lotion have shown a good effect of skin whitening, moisturizing and recovering the skin barrier. The POND＇S ultra luminous day cream shows a better effect on skin whitening.