铜绿假单胞菌下呼吸道感染的临床特点和药物敏感性

Clinical Manifestations and Drug susceptibility of Low Respiratory Tract Infection by Pseudomonas Aeruginosa

目的 :分析和总结下呼吸道铜绿假单胞菌感染的临床特点和抗生素敏感性的分布情况。方法 :对 70例铜绿假单胞菌下呼吸道感染的临床资料进行统计分析 ,采用纸片法 (Kirby Bauer)测定该菌的体外药物敏感性。结果 :70例中 83 % (5 8/70 )患有基础疾病 ,其中慢性阻塞性肺疾病 (COPD)合并呼吸衰竭最常见。临床表现为发热、咳嗽、咳痰。胸部X线多表现为双下肺斑片状阴影。药敏监测该菌对复达欣、环丙沙星、多粘菌素B、氨基糖甙类等药物敏感。结论 :铜绿假单胞菌下呼吸道感染多有基础疾病 ,抵抗力低下。临床表现中毒症状严重 ,诊断与治疗有赖于细菌培养和药物敏感性。

Objective: To Analyze clinical manifestations and summarize drug susceptibility of low respiratory tract infection caused by pseudomonas aeruginosa (PA). Method: To analyze the clinical data of 70 cases with low respiratory tract infection caused by pseudomonas aeruginosa and determine drug sensitivities against PA by means of Kirby Bauer. Results: 58 of the 70 cases ( accounting for 83%) had underlying diseases, most often were COPD with respiratory failure. The main clinical symptoms were fever, cough and expectoration. Chest X ray revealed spots in lower lobes of both sides. Drug test showed that PA was susceptible to ceftazidime, ciprofloxacin, polymyxin B and aminoglycosides. Conclusions: Most cases of low respiratory tract infection caused by PA are susceptible to underlying drugs and patients have low resistance. Clinical manifestations showed serious intoxicating symptoms. Diagnosis and treatment depend on bio culture and antimicrobial sensitivity test.