钝顶螺旋藻多糖降血糖调血脂实验研究

Research of Polysaccharide from Spirulina platensis on Hypoglycemic and Hypolipidemic Effect in Experimental Diabetic Rats

目的 :观察螺旋藻多糖 (PSP)对四氧嘧啶 (ALX)性糖尿病大鼠血糖、血脂水平的影响。方法 :用ALX建立糖尿病大鼠模型 ,分别用PSP 0 .1、0 .2 g/kg及阳性对照药苯乙双胍 0 .350 g/kg灌胃治疗 ,正常对照组及糖尿病模型对照组则给等容积生理盐水。连续给药 1 4d后 ,分别测定各组大鼠血糖、血脂。结果 :PSP 0 .1、0 .2 g/kg能明显降低ALX所致糖尿病大鼠高血糖 ,与糖尿病模型对照组相比 ,P <0 .0 1 ;同时 ,相同剂量的PSP还能明显降低ALX性糖尿病大鼠血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇 (P <0 .0 1 )。PSP 0 .2 g/kg还使糖尿病大鼠血清HDL C显著回升 (P <0 .0 5) ,而PSP 0 .1 g/kg对糖尿病大鼠血清HDL C则无明显影响 (P >0 .0 5)。 结论

Purpose:The aim is to observe the effects of polysaccharide from Spirulina platensis (PSP) on hyperglycemia and hyperlipidemia in alloxan induced diabetic rats.Methods:The diabetic model rats were established by intra abdominal injection of alloxan.Then the living diabetic rats were divided into four groups.Among them,two groups were treated with PSP 0.1 ,0.2 g/kg respectively by ig administration, and one group was given phenfomide 0.35 g/kg by ig adminstration as the positive control,and another group was given normal saline as the diabetic model control.The normal control group was tested on the normal rats by ig saline.After 14 days of treatment,the blood glucose and the serum lipids content of each group were detected.Results:Compared with the diabetic model control group,PSP 0.1 and 0.2 g/kg could significantly decrease the blood glucose in diabetic rats( P< 0.01).At the same time,the results also showed that PSP could remarkably decrease the level of serum TC,TG and LDL C in diabetic rats.In addition,PSP 0.2 g/kg could obviously increase the serum contents of HDL C in the rats ( P<0.05 ),but PSP 0.1 g/kg had no significant effects on serum HDL C in diabetic rats.Conclusion:PSP had significant effects on hypoglycemic and hypolipidemic action in diabetic rats induced by alloxan.