超顺磁性氧化铁微粒对肝脏占位病变的诊断意义

Diagnostic Value of Superparamagnetic Iron Oxide Particle Enhancement MRI in Hepatic Space-Occupied Lesions

目的：评价超顺磁性氧化铁（ＳＰＩＯ）对肝脏占位病变的显示及定性作用。材料和方法：３０例肝脏占位性病变，其中包括原发性肝癌（ＨＣＣ）、胆管细胞癌、转移性肝癌、局灶性结节增生、血管瘤及肝硬化结节。静脉注射ＳＰＩＯ后，用１．５Ｔ超导型ＭＲ扫描机分别对病灶行 １０ｍｉｎ、 ３０ｍｉｎ、 ４５ｍｉｎ、 ７０ｍｉｎ和 １６ｈ动态扫描。计算肝实质和病灶的增强信噪比（ＣＮＲ）和肝实质的相对强化比（ＲＥ）。并绘制其时间一信号强度曲线。结果：扫描结果显示在自旋回波和梯度回波的Ｔ２加权序列中，肝实质呈明显负性强化。肝内病灶中肝转移瘤信号强度无明显变化。ＨＣＣ可呈轻度负性强化。肝血管瘤等良性病灶信号在扫描延迟可见轻度正性强化作用。结论：ＳＰＩＯ在Ｔ２加权中的负性强化作用对肝肿瘤的显示有良好的信噪比，对肝肿瘤的定性诊断是值得探讨的领域。

To evaluate the diagnostic value of superparamagnetic iron oxide particles (SPIO) enhancement MRI in liver space-occupid lesions. Materials and Methods: 30 patients with liver lesions were studied with SPIO enhancement MRI. The contrast noise rate (CNR) of lesion to liver and the relative enhancement rate (RE) of liver were measured at 10、30、 45、 7、0 min and 16 hour after the injection of SPIO. The dynamic curves of signal-noise for each case were made and analysed. Results: The hepatic parenchyma had a significantly negative enhancement in SE and GRE TZ weighted images. However, the signal showed few changes in hepatic metastases and only a little postitive or negative enhancement in hemangiomas, HCC and FNH. Conclusion: SPIO, as a negative contrast media for liver, has a significantly efficacy to show liver lesions and as a liver lesion-specific contrast MR agent, is worth being explored.