静吸复合与全凭静脉2种麻醉方式对乳腺癌炎性细胞因子的影响

Influence of intravenous inhalation anesthesia and total intravenous anesthesia on inflammatory cytokines of patients with breast cancer

目的探讨静吸复合麻醉及全凭静脉麻醉2种麻醉方式对乳腺癌患者炎性细胞因子的影响。方法选取2011年11月—2012年10月在本院乳腺外科行手术治疗132例乳腺癌患者,随机分为A(静吸复合组,n=66)、B(全凭静脉组,n=66)2组,分别给予静吸复合麻醉与全凭静脉麻醉,于麻醉前、术后4 h、术后6 h进行血白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)检测并对比分析。结果 2组患者IL-6、TNF-α水平均显著增高(P<0.05),术后6 h A组IL-6显著高于B组(P<0.01),术后4 h、6 h A组TNF-α均显著高于B组(P<0.01)。结论全凭静脉麻醉在乳腺癌患者中能够更好地抑制术后血清IL-6及TNF-α等炎性细胞因子的增高,避免过度应激反应,值得推广。

Objective To explore the influence of intravenous inhalation anesthesia and total intravenous anesthesia on inflammatory cytokines of patients with breast cancer. Methods 132 breast cancer patients treated with operation were randomly divided into group A（ intravenous inhalation anesthesia, n = 66） and group B（total intravenous anesthesia, n = 66）. Levels of IL-6 and TNF-α were detected and compared in both groups. Results After the operation, the levels of IL -6 and TNF-α were significantly higher than those before the operation in both groups（P〈 0.05）. IL-6 level in the group A was significantly higher than group B at the time of 6 hours after the operation（ P 〈 0.01）, and TNF-α were significantly higher than group B at the time points of 4 and 6 hours after the operation （ P 〈 0.01 ）. Conclusion Total intravenous anesthesia can suppress the postoperative increasing of serum IL-6, TNF-α and other inflammatory eytokines in patients with breast cancer in order to avoid excessive stress, so it is worthy of popularization.