西酞普兰对功能性消化不良患者焦虑、抑郁症状的影响

Influence of citalopram on anxiety and depression of patient with functional dyspepsia

目的观察西酞普兰对功能性消化不良(FD)患者焦虑、抑郁症状的影响。方法将132例FD患者随机分为治疗组68例和对照组64例,对照组给予奥美拉唑与莫沙必利,治疗组在此基础上,加用抗抑郁剂西酞普兰,并给予相应心理指导。分别采用抑郁自评量表(SDS)及焦虑自评量表(SAS)对抑郁、焦虑障碍进行评定,观察2组治疗前及治疗第2、4、8周FD症状积分的变化、临床疗效及不良反应发生情况。结果 132例患者中,60例发生抑郁障碍,53例发生焦虑障碍;治疗第2、4、8周,治疗组SDS及SAS标准分均显著低于对照组,且治疗第4、8周,FD症状积分明显低于对照组,而总有效率明显高于对照组,差异均有统计学意义。2组治疗前后均未见明显异常现象。结论 FD患者普遍存在焦虑、抑郁情绪,而在常规治疗基础上加用西酞普兰可显著改善患者抑郁、焦虑障碍,缓解症状,疗效显著,且不良反应少。

Objective To observe the influence of citaloprarn on anxiety and depression of patient with functional dyspepsia （FD）. Methods One hundred and thirty-two FD patients were randomly divided into treatment group （n = 68） and control group （n = 64）. The patients in control group were given omeprazole and mosapride, while the patients in the treatment group were added citalopram based on the treatment in the control group, and meanwhile given corresponding psychology guidance. The anxiety and depression disorders were evaluated respectively by Self-rating Depression Scale （SDS） and Self-rating Anxiety Scale （SAS）. The symptomatic scores before treatment and on the second, fourth and eighth week of treatment, clinical efficiency and adverse reactions were observed in the two groups. Results Among 132 patients, there were 60 with depression and 53 patients suffering from anxiety. SDS and SAS scores on on the second, fourth and eighth week of treatment and FD symptomatic scores on the fourth and eighth weeks of treatment were obviously lower, while the overall response rate was significantly higher in treatment group than that in the control group. So the difference was statistical significant. Before and after treatment, there were no abnormal patients in two groups. Conclusion FD patients are usually accompanied by anxiety and depression. The application of citalopram on the basis of routine treatment could significantly ameliorate the patients＇ anxiety and depression, alleviate symptoms, improve the efficiency and reduce adverse reactions.