护理干预配合阿司匹林在2型糖尿病患者中一级预防心血管事件的临床应用

The clinical application of aspirin combined with nursing intervention in primary prevention of cardiovascular events of patients with type 2 diabetes

目的检验糖尿病患者应用阿司匹林(ASA)进行一级预防心血管事件的疗效,观察通过本院相关护理干预减轻ASA不良反应的效果。方法本研究共纳入研究对象200例,随机分为实验组和对照组各100例。实验组予ASA 100 mg/d口服,对照组给予安慰剂。观察1年后2组患者血清化学成分变化、心血管意外事件发生率以及通过特色护理干预后实验组因服药出现的胃肠道症状缓解情况。结果 ASA能显著降低LDL、TG、TC和CRP水平,提高HDL水平;除卒中外实验组主要心血管事件发生率均显著低于对照组(P<0.05);因口服ASA引起胃肠道症状的实验组在系统、科学、无缝隙的护理干预后明显好转。结论糖尿病患者应用ASA能显著减少心血管事件,系统、科学、无缝隙的护理干预能有效减轻ASA引起的胃肠道症状。

Objective To explore the effect of aspirin （ASA） in primary prevention of cardiovascular events of patients with type 2 diabetes and to reduce adverse effects of ASA through the appropriate nursing interventions. Methods A total of 200 patients with type 2 diabetes were randomly divided into experimental group and control group with 100 patients in each group. Experimental group were given 100mg aspirin every day and the patients in control group were given placebo only. The changes of chemical composition in serum, occurrence rate of cardiovascular and remission of gastrointestinal symptoms caused by taking ASA in experimental group were recorded and analyzed. Results ASA can significantly reduce LDL, TG, TC and CRP levels and improve HDL levels. The incidence rate of major cardiovascular events in experimental group were significantly lower than that in the control group except stroke （P 〈 0.05）. After scientific and system-atic nursing, gastrointestinal symptoms caused by taking ASA in the experimental group were significantly relieved. Conclusion Diabetes patients can significantly reduce occurrence of cardiovascular by taking ASA. Scientific, systematic and seamless nursing intervention can apparently re- duce adverse reaction in gastrointestinal symptoms caused by taking ASA.