万古霉素微量泵控制持续鞘内注射治疗颅内感染

Microinjection pump control continuous intrathecal injection of vancomycin for the treatment of intracranial infection

目的探讨利用微量泵控制下持续鞘内注射万古霉素治疗颅内相关感染的临床疗效。方法观察2009年1月—2012年10月本院收治的各类颅内感染病例50例,其中22例行腰大池引流脑脊液并分次鞘内注射万古霉素治疗作为对照组,28例在上述基础上改用微量泵控制下持续鞘内注射万古霉素治疗为实验组,观察2组间的疗效差异。结果实验组对体温、血象、脑脊液等的观察指标较对照组改善迅速,而腰腿痛、抽搐、头痛等副反应观察指标较对照组明显减少。结论腰大池持续引流脑脊液并微量泵控制下持续鞘内注射万古霉素是治疗颅内感染的一种安全有效的方法。

Objective To study the clinical curative effect of continuous intrathecal injection of vancomycin controlled by microinjection pump in the treatment of intracranial infection. Methods 50 patients with intracranial infections from January 2009 to October 2012 were included in the research. 22 patients treated with cerebrospinal fluid drainage from lumbar cistern and discontinuous intrathecal injection of vancomycin were in control group, and another 28 patients with continuous intrathecal injection of vancomycin by micropump were in the experimental group. Therapeutic effect was observed between the two groups. Results The patients in the control group improved more rapidly than those in the experimental group in the temperature, blood, cerebrospinal fluid and other observation index. Compared with the control group, the pain of lower back and leg, convulsions, headache and other side effects were significantly reduced in the experimental group. Conclusions Continuous drainage of cerebrospinal fluid in lumbar cistern and microinjection pump control continuous intrathecal injection of vancomycin is a safe and effective method to treat intracranial infection.