多发性骨髓瘤患者血脂水平的变化及其临床意义

Changes of blood lipid levels in patients with multiple myeloma and its clinical significance

目的探讨多发性骨髓瘤(MM)患者血脂变化及其与临床分期的关系。方法选取本院收治的112例初诊MM患者作为MM组,同时选取80例正常体检者作为正常对照组,比较2组化疗前的血脂水平,不同分期MM患者血脂水平及其化疗前后的血脂水平,包括甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。结果化疗前,MM组血清TC、HDL-C及LDL-C水平均明显低于正常对照组,而TG水平与正常对照组比较差异无统计学意义。Ⅲ期患者血清TC、HDL-C和LDL-C水平均明显低于正常对照组,Ⅱ期患者血清LDL-C水平明显低于正常对照组,而Ⅰ期患者血脂水平与正常对照组比较差异无统计学意义。经2个疗程化疗后,治疗有效者TC及HDL-C水平明显高于化疗前。结论血脂水平可以辅助MM的诊断及对临床分期和预后的判断。

Objective To investigate the changes of blood lipid in the patients with multiple myeloma （MM）and the relationship with clinical stage. Methods 112 initially-diagnosed patients with MM and 80 healthy people were respectively as MM group and normal control group. The levels of blood lipid before chemotherapy in two groups and MM patients with different clinical stages as well as the levels before and after chemotherapy were compared. Triglyceride （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C） were included. Results Before chemotherapy, the levels of TC, HDL-C and LDL-C in MM group were significantly lower than that in normal control group, but the difference was not significant compared with TG levels. The levels of TC, HDL-C and LDL-C in phase Ⅲ and LDL-C in phase Ⅱ were all significantly lower than that in normal control group, and the difference was not significant compared with the levels of blood lipid in phase I .After 2 courses of chemotherapy, the levels of TC and HDL-C in effectively treated patients were obviously higher than that before chemotherapy. Conclusion The level of blood lipid is helpful to diagnose patients with MM and to evaluate the clinical staging and prognosis.