炎症反应与子痫前期进展的临床相关性

Clinical correlation between inflammatory reaction and progress of eclampsism

目的探讨子痫前期患者炎症反应在子痫前期进展中的表达及意义。方法选取子痫前期患者100例(子痫前期组),其中轻度子痫前期40例,重度子痫前期60例。另选择健康孕妇60例作为对照组。测定并比较2组血清hs-CRP、IL-6、TNF-α水平。结果子痫前期组IL-6、hs-CRP及TNF-α水平显著高于对照组,差异有统计学意义(P<0.05),且重度子痫前期患者IL-6、hs-CRP及TNF-α水平显著高于轻度子痫前期患者,差异也有统计学意义(P<0.05)。结论子痫前期患者不仅存在过度的炎症反应,而且随病情进展而加重,早期干预血脂异常可能有助于控制子痫前期的发生和发展。

Objective To explore the expression and significance of inflammatory reaction in patients with progress of eclampsism. Methods 100 patients with eclampsism were designed as eclampsism group, which including 40 cases of mild eclampsism and 60 cases of severe eclampsism. 60 healthy pregnant women were designed as control group. Levels of IL-6, hs-CRP and TNF-α were detected and compared between two groups. Results Levels of IL-6, hs-CRP and TNF-α in eclampsism group were significantly higher than those in control group （P 〈 0.05）, and levels of indexes mentioned above in severe eclampsism group were significantly higher than those in mild eclampsism group as well （ P 〈 0.05）. Conclusion Excessive inflammatory reaction can be ob- served in patients with eclampsism. Early intervention on abnormal blood fat level may help control the occurrence and development of eclampsism.