透析护理干预对干扰素治疗尿毒症伴丙肝病毒感染患者不良反应的效果分析

The effect analysis of nursing intervention on adverse reactions of patients with uremia combined with HCV infection treated by interferon during hemodialysis period

目的分析透析间期使用干扰素(IFN)治疗的维持性血液透析伴丙肝病毒(HCV)感染患者治疗中产生的不良反应,探讨在透析过程中进行有针对性的护理干预对透析患者丙肝治愈率的影响。方法对9例维持性血液透析伴HCV患者在透析间期运用干扰素皮下注射治疗6个月,治疗期间针对患者产生的不良反应在透析中采取个体化的护理措施,于治疗3个月、6个月、停药后6个月分别检测病毒定量指标。结果 9例患者除2例患者因副作用终止治疗,其余患者完成疗程。早期应答率78%;治疗结束时78%的患者血清ALT正常,血清HCV-RNA阴性(<1000 IU/mL);在随访6个月时,持续应答率100%。结论针对透析伴HCV患者干扰素治疗期间的不良反应,在透析中采取个体化的护理对策能明显提高患者治疗依从性,达到丙肝临床治愈标准,提高生存率。

Objective To analyze adverse reactions of patients with uremia combined with HCV infection treated by interferon during hemodialysis period and to explore the cure rate of nursing intervention. Methods 9 patients with HCV during hemodialysis period were injected with subcutaneous interferon for 6 months. The adverse reactions during treatment were given individualized nursing measures during dialysis. Quantitative indicators of virus were detected after 3 months, 6 months and 6 months after the drugs stopped. Results There were 7 patients completed the treatment and 2 patients discontinued treatment due to side effects. Early response rate was 78 %. ALT in serum in 78 % patients was normal at the end of treatment, HCV-RNA in serum was negative （〈 1000/ml）. Sustained response rate of follow-up was 100 % after 6 months. Conclusion Individualized nursing for dialysis patients with HCV treated by interferon could significantly improve treatment compliance and achieve clinical cure efficacy.