SF、LDH和γ-GT检测在乳腺癌诊断治疗中的临床应用价值

Study on clinical significance of SF,LDH and gamma GT testing in diagnosis of breast cancer

目的探讨血清铁蛋白(SF)、乳酸脱氢酶(LDH)和γ-谷氨酰转肽酶(γ-GT)检测在临床乳腺癌诊断及治疗疗效判断中的应用价值。方法收集2010年2月至2013年8月乳腺癌患者42例,乳腺良性肿瘤患者57例和正常健康女性85例,分别用化学发光免疫法测定SF,用生化速率法测定LDH和γ-GT的含量,并对所测数据进行分组比较分析。结果乳腺癌血清中SF、LDH和γ-GT含量显著高于乳腺良性肿瘤患者和正常健康女性,两组差异有显著性(P<0.01);SF、LDH和γ-GT含量随乳腺癌临床分期的增加而显著增加,随手术或治疗效果好转而迅速下降,复发时再次增高;SF、LDH和γ-GT对乳腺癌诊断的敏感度分别为64.9%、81.2%和87.5%。结论 SF、LDH和γ-GT含量检测对乳腺癌临床诊断有一定的参考价值,特别对乳腺癌治疗效果的判断有极为重要的临床应用价值。

Objective To explore the diagnostic significance of serum ferritin （ SF）, lactate dehydrogenase （LDH） and γ - glutamyl-transpeptidase （ γ- GT） in diagnosis and judgement of efficacy in treatment of breast cancer. Methods The clinical data of 42 patients with breast cancer, 57 patients with breast benign tumour and 85 normal healthy women during February 2010 to August 2013 were collected for this study. Serum ferritin （SF） was measured by chemiluminescence immunoassay, the levels of LDH and γ- GT were determined by biochemical method, and their results were grouped and comparatively analyzed. Results The serum levels of SF, LDH and T - GT in patients with breast cancer were significantly higher than those of patients with breast benign tumour and normal healthy women, and the difference in results between them was statistically significant （ P 〈 0.01 ）. The levels of SF, LDH and 3, - GT were significantly increased followed with the increase of clinical staging of breast cancer, and they were rapidly dropped after surgery or improved after treatment, and they were increased again with the recurrence of the disease. The sensitivity rates of SF, LDH and γ- GT in diagnosis of breast cancer were 64.9%, 81.2% and 87.5% respectively. Conclu- sion The determination of levels of SF, LDH and gamma GT has certain referential value in clinical diagnosis of breast cancer, especially in the assessment of efficacy of treatment for breast cancer, hence it has extremely important clinical value.