糖尿病足与糖尿病下肢动脉病变及预后的相关性研究

The correlation research of diabetic foot with peripheral arterial disease and prognosis

目的探讨糖尿病足与下肢动脉病变及预后的相关性。方法以2009年2月至2012年6月收治的75例糖尿病患者作为研究对象,将其中35例糖尿病足患者列为DF组,将40例非糖尿病足患者列为非DF组。比较两组患者下肢动脉病变的发生情况,随访1年根据患者是否截肢分为截肢组和非截肢组,并对两组患者的一般情况和相关因素进行统计分析。结果 DF组患者下肢动脉病变的发病率明显高于非DF组,且DF组并发重度下肢动脉病变的患者显著多于非DF组,随访1年后,DF组35例患者中截肢8例,截肢率22.9%,其中糖尿病合并感染和既往有截肢史是糖尿病足患者1年内发生截肢的独立危险因素。结论经双下肢彩色多普勒检查并评定为严重下肢动脉病变以及PAD评分较高的糖尿病患者其1年内病发糖尿病足的几率较高,与合并感染以及既往有截肢史同为影响其预后的独立危险因素,临床可据此及早对伴有上述危险因素的患者给予针对性的治疗。

Objective To discuss the correlation of diabetic foot with peripheral arterial disease and prognosis. Methods 75 cases of diabetic patients in our hospital from February 2009 to June 2012 were included into this study and treated as the research objects. These objects included 35 patients with diabetic foot, classified as the DF group, and 40 cases of patients not with diabetic foot as the no - DF group. To compare occurrence of peripheral arterial disease in patients of two groups. All patients were followed up for 1 year. According to whether patients with am- putation, these patients were divided into the amputation group and the non amputation group. The general situation and related factors of patients in two groups were compared and analyzed. Results The incidence of peripheral arterial disease in patients of two groups had obvious differences. The patients with severe peripheral arterial disease in the DF group were significantly more than that in the no - DF group. After 1 year following up, 8 cases had amputation in 35 cases of the DF group, the amputation rate was 22.9%. Patients combined with diabetic foot, infection and the history of amputation are independent risk factors for amputation occurred in a year. Conclusion The patients with assessment through the color Doppler ultrasonography of both lower extremities of severe lower limb arterial lesions, higher PAD score had higher invasion probability of diabetic foot in 1 year. They were the independent risk factors for the prognosis as with combined infection, history of amputation. The physician should give targeted therapy to patients with these risk factors as soon as possible.