秦氏隐血珠在上消化道癌初筛普查中实用价值的调查研究——附31972例初筛人群5、10年随访资料分析

Investigation of the utility value in Qin' s hemoccult test bead for screening of upper digestive tract

目的:通过对隐血珠初筛人群及癌患者5年、10年随访,进一步证实隐血珠对上消化道癌初筛普查的实用价值。方法:空腹时吞入隐血珠,3～5分钟拉出,观察珠内试纸的变化,黄色为阴性（-）,浅蓝色为（+）,蓝色为（++）,深蓝色为（+++）,5年、10年后对隐血珠初筛人群及癌患者通过三级防癌网络进行全员随访。结果:初筛普查31927人,阳性组3347人做胃镜,经病理确诊为癌患者125人,癌检出率3.74％;阴性组645人做胃镜,确诊癌患者9人,癌检出率1.4％,两组中早期癌患者共78人,占62.4％,性别、年龄、隐血珠反应均是影响癌检出率的因素,经5年及10年两次全员随访资料统计,隐血珠初筛阳性组癌发生率均明显高于阴性组,癌患者5年生存率67.2％,10年生存率为55.2％,性别、年龄、隐血珠反应也是影响上消化道癌发病率的因素。结论:秦氏隐血珠在上消化道癌初筛普查中有肯定的实用价值,值得推广。

Objective: To investigate the utility value of Qin' s hemoccult test bead in screening of upper digestive tract cancer. Methods:Bead, Swallowed and retained in the stomach for 3 to 5 minutes, was able to sort out the individuals by its coloration:yellow(-), light blue(+), blue(++), and dark green(+++), and we investigated the screening crowd and cancer patients after 5 years and 10 years through the three-drgree cancer prevention net.Results: We screened 31927 normal subjects, and 3347 subjects were found positive and were examined by gastroscope, and 125 subjects were found to be cancer with pathology, the relevance rate is 3.74% . 645 subjects in negative group were examined by gastroscope, and 9 subjects were found to be cancer, the relevance rate is 3.74% . The early cancer among the two groups were totaled to 78 subjects(62.4% ), In our 5 and 10 years' studies, Cancer occur ratio have distinct different between the positive and negative group. The 5, 10 year surrival rate is 67.2% and 55.2% . Sex, age and reaction level of hemoccult were three important factors which influence the cancer relevance ratio and occur rate. Conclusions: Hemoccult test bead of Qin has definite utility value in screening upper digestive tract cancer, and has value to be recommended widely.