脑梗死患者颈动脉内膜-中膜厚度与LDL、OX-LDL关系的研究

Study on intima media thickness of carotid artery and relation between it and LDL or OX-LDL

目的 研究脑梗死患者颈动脉粥样硬化的程度,分析低密度脂蛋白(LDL)、氧化低密度脂蛋白(OX-LDL)与颈动脉粥样硬化的关系。方法 B超测定脑梗死组及对照组的颈动脉内膜-中膜厚度(intimalmedia thickness;IMT)。测定受试者的LDL、OX-LDL。比较各脑梗死组及对照组的IMT和LDL、OX-LDL。对IMT和LDL、OX-LDL相关分析。结果 伴糖尿病的脑梗死组IMT高于其它脑梗死组及对照组。IMT与LDL、OX-LDL显著正相关。结论 脑梗死患者的颈动脉粥样硬化程度显著高于对照组; 其中伴有糖尿病的脑梗死患者的颈动脉粥样硬化程度尤为明显, LDL、OX-LDL是促进颈动脉粥样硬化的关键因子。

Objective To explore the level of artheroscle rosis in carotid artery of cerebral infarction patients, analyse the relation between artherosclerosis and serum LDL ,OX-LDL. Methods Determine the intima media thickness(IMT) of car otid artery in cerebral infarction patiens and control. Measure low density lipoprotein(LDL) and oxided low density lipopro tein(OX-LDL) in their serum, Compare IMT and serum LDL,OX-LDL in cerebral infarction patien ts groups. Analyse the correlation between IMT and serum LDL,OX-LDL. Result IMT in the group of cerebral infarction accompanied diabetes was higher than the other groups . IMT was significantly positively correlated with LDL,OX-LDL. Conclusion Patien ts with cerebral infarction, especially those acompanied with diabetes have more severe artherosclerosis chan ge in carotid artery. LDL,OX-LDL are crucial factors that could expedite artherosclerosis of carotid artery.