Ku抗体在自身免疫性结缔组织病中的意义

Significance of anti-Ku antibody in antoimmune connective tissue diseases

目的 探讨Ku抗体在我国结缔组织病 (CTD)中的分布及其临床意义。方法 制备兔胸腺丙酮粉 ,提取Ku抗原 ,以免疫双扩散法测定 5 0份正常人和 438份不同CTD患者血清中Ku抗体阳性率 ,分析Ku抗体阳性患者的临床和实验室特点。结果 438份CTD患者血清中 12例Ku抗体阳性 ,其中系统性硬化症多发性肌炎重叠结缔组织病 (SSc PM )占 9例。对SSc PM而言 ,Ku抗体的敏感性 6 0 0 % ,特异性 99 4%。Ku抗体阳性的SSc与阴性的SSc比较 ,发现阳性的SSc患者多同时有肌炎表现 ,两组间差异有极显著性 (P <0 0 1)。结论 Ku抗体并非常见 ,对SSc而言 ,Ku抗体与肌炎显著相关。Ku抗体阳性的SSc可能是SSc中的另一亚型 ,其临床特点还待更多病例观察随访。

Objective To explore Ku Ab distribution in connective tissue disease (CTD) in China and its clinical significance.Method Ku antigen was extracted from rabbit thymus and was used to detect Ku Ab in the sera of 50 normal controls and 438 CTD patients by double immunodiffusion.Results Among the 438 CTD patients,12 had positive Ku Ab,and among the 15 systemic sclerosis polymyositis (SSc PM) overlap syndrome,9 had positive Ku Ab.As for SSc PM,the test of Ku Ab had a sensitivity of 60 0% and a specificity of 99 4%.Compared with Ku Ab negative SSc patients,all of the Ku Ab positive patients had concomitant myositis ( P <0 01).Conclusion Anti Ku antibody is not common,but there is significant relevance between Ku Ab and PM in SSc.SSc with positive Ku Ab may be a subclass,while its clinical characteristics are yet to be further studied.