精神分裂症患者一级亲属的静息态功能磁共振低频振幅研究

Amplitude of low-frequency fluctuations of the first-degree relatives of schizophrenia patients： a resting-state functional magnetic resonance imaging study

目的运用fMRI方法探讨精神分裂症患者的一级亲属在静息状态下的脑功能特点。方法招募精神分裂症患者的未患病的生物学父亲或母亲55名（父母组），以年龄、性别及教育程度与之基本匹配的健康人29名为对照（对照组），南经验丰富的精神科医生对被试者进行非结构性访谈。被试者进行静息状态下全脑fNRI，采用低频振幅作为测量指标，比较父母组与对照组之间的静息脑功能的差异。结果与对照组相比，父母组低频振幅减弱的脑区主要位于有侧的颞中回、中扣带、额上回／额中回、额下回三角部以及双侧的角回；父母组低频振幅增强的脑区主要位于双侧的舌回[左侧：蒙特利尔神经科学研究所坐标（x、y、z）为-12、-81、3，t=4．08；有侧：蒙特利尔神经科学研究所坐标（x、y、z）为9、-57、3，t=3．88；均P〈0．01，已校正]。结论精神分裂症患者一级亲属在静息状态下存在多个脑区功能异常，可能与精神分裂症的遗传易患性有关。

Objective To explore the differences of brain function between the first-degree relatives of schizophrenia patients and normal controls with resting-state functional magnetic imaging （fMRI）. Methods Fifty-five unaffected biological fathers or mothers of schizophrenia patients and twenty-nine age- and gender-matched controls were enrolled and screened by experienced psychiatrists with a unstructured interview in this study. Then a resting-state fMRI scan was conducted for each participant. Amplitude of low- frequency fluctuations （ALFF） approach was used to explore the differences of resting-state brain function between parents and eontrols. Results Compared with the controls, unaffected parents showed significantly decreased ALFF in the right middle temple cortex, middle eingulate cortex, superior frontal cortex/middle frontal cortex, triangular part of inferior frontal cortex and bilateral angular cortices. Parents also showed significantly increased ALFF in the bilateral lingual cortices （ left ： Montreal Neurological Institute （ x, y, z ） ： - 12, - 81,3, t = 4. 08, right： Montreal Neurological Institute （ x, y, z ） ： 9, - 57,3, t = 3.88, P 〈 0.01, corrected）. Conclusions The results indicate there are dysfunctions of brain areas in the first-degree relatives of sehizophrenia patients during resting state,which may reflect a genetic risk for schizophrenia.