活血通络法治疗强直性脊柱炎78例临床研究

The clinical study of Huoxuetongluo method on treatment of 78 Ankylosing Spondylitis patients

目的研究活血通络法治疗强直性脊柱炎(AS)的临床疗效。方法本研究共纳入AS患者78例,采用随机对照的方法,疗程12周,将患者按1:1随机分为治疗组和对照组,治疗组39例,予尪痹颗粒+活血通络汤口服,脱落1例;对照组39例,予尪痹颗粒口服,其中脱落2例。以纤维蛋白原、血小板计数、血沉(ESR)、C反应蛋白(CRP)、BAS-G(AS患者总和指数)、指地距、IgG、晨僵时间、Schober试验作为观察指标,以中医疗效评价标准进行临床疗效评价。评价患者不良反应的发生情况。结果 78例患者入选本研究,共脱落3例,12周后,治疗组ESR、血小板计数、纤维蛋白原较对照组明显改善,差异有显著性(P<0.01),晨僵时间、指地距、Schober试验、中医证候积分较对照组改善,差异有显著性(P<0.05),两组治疗后IgG、CRP、BAS-G比较无明显差异,差异无显著性(P>0.05),治疗组疗效优于对照组。两组无明显不良反应。结论运用活血通络法中药治疗强直性脊柱炎患者有确切疗效,能改善患者的症状、体征和实验室指标,而且用药安全,无明显毒副作用。

Objective To observe the clinical effect of Huoxuetongluo method on Ankylosing Spondylitis（ AS） . Method To adopt the way of randomicity,comparison. The treatment took 12 weeks. 78 AS patients were randomly assigned to treatment group and comparison group. 39 examples of treatment group use Wangbikeli＋Huoxuetongluo soup, 1 example was expulsed;39 examples of comparison group use Wangbikeli, 2 examples were expulsed; fibrinogen、blood platelet、ESR、CRP、BAS-G、distance between finger and ground,IgG,stiff time, Schober test were observed as the observing indexes, and criterion of TCM medicine were explored for clinical evaluation and safety e-valuation. Result 78 examples were selected in this research, 3 examples were expulsed. In comparison with the treatment group, the efficacy of treatment group had more positive effect（P〈0. 01）, mainly on ESR、blood platelet、fibrinogen,had positive effect（P〈0. 05）, mainly on stiff time, distance between finger and ground, Schober test、syndrome of Traditional Chinese Medicine, had no obvious difference on IgG、CRP、BAS-G（P〉0. 05）. The treatment group had more better effect than comparison group. There are no obvious bad effect in treatment group and compari-son group. Conclusion Huoxuetongluo method has obvious effect on the patient of AS, and can relieve the clinical symptoms of AS, improve Medical signs, Further more, Huoxuetongluo method has not side-effects.