锌对血液粘度及凝血酶原时间影响的实验研究

Experimental Studies of Effects of on Blood Viscosity and Prothormbin Time

目的 :探讨锌对机体锌、铜代谢、血液粘度及凝血酶原时间的影响。方法 :采用新西兰大白兔饮水中加葡萄糖酸锌 (锌含量 1 5.3mmol/L )喂养 ,设正常组对照 ,满 1 2个月后取血及肾组织测定锌、铜、血液粘度、血脂及凝血酶原时间。结果 :加锌组较对照组血清及肾脏锌含量显著升高 (P<0 .0 1 ) ,分别为 4.99倍、1 .79倍 ,全血粘度 (高切、中切、低切 )及血浆粘度明显升高(P<0 .0 5～ 0 .0 1 ) ,凝血酶原时间缩短 (P<0 .0 1 ) ,胆固醇、甘油三酯及血糖升高 (P<0 .0 1 ) ,红细胞数量及质量没有变化 (P>0 .0 5)。结论 :补锌能提高内环境锌水平 ,锌可通过干扰脂代谢引起血液粘度增加 ,凝血酶原时间缩短 ,合理用锌对于防治缺血性心脏血管病有重要意义。

Objective:To study the effect of zinc on zinc,copper,blood viscosity and prothonmbin time.Methods:20 New zealand wite rabbits were devided into 2 groups.(control group and glucose zinc supplemental group).Hemorrheology of all rabbits in glucose zinc (150.0 mmol/L).Results:Compared with that of control group zinc's content rose markedly(P<0.01) in serum and kidney and whole blood viscosity,plasma viscosity,blood-fat and blood glucose were increased significantly (P<0.05～0.01),prothormbin time was shorted (P<0.01) and erythrocyte sedimentation rate was speeded.(P<0.01),but number and quality of red cells were not changed (P>0.05)in the rabbits of zinc supplemental group.Conclusions Zinc may result in increased blood viscosity by interfering lipid metabolism,thus the suitable use of zinc is very singnificant for the prevebtion and treatment of diseases on heart,brain blood vessel.