颅内肿瘤组织中微量元素锌和铜含量研究

The studies of trace elements zinc and copper levels in tumor tissue

目的 :探讨微量元素锌和铜与颅内肿瘤生物活性的关系。方法 :应用原子吸收分光光度计测定 61例颅内肿瘤组织中微量元素锌和铜的含量与对照组 32例正常脑组织微量元素锌和铜的含量比较。结果 :锌的含量平均值是恶性肿瘤组织 (94.90± 1 8.39μg/ g) >良性肿瘤组织(83.30± 2 0 .52 μg/ g) >正常脑组织 (51 .44± 1 3.6μg/ g) ;铜的含量平均值是恶性肿瘤组织(2 8.76± 1 1 .65μg/ g) >良性肿瘤组织 (1 8.2 5± 7.1 3μg/ g) >正常脑组织 (1 1 .2 5± 5.1 9μg/g)。结论 :微量元素锌和铜与颅内肿瘤的恶性程度有关 ,铜的缺乏可能是导致肿瘤卒中的原因 ,缺铜可抑制颅内肿瘤的生长。

Objectiue:To study correlation of trace element zinc and copper and intracranial tumor bioactivity.Method:We used atomic absorption spectrophotometry to measure content of zinc and copper in tumor tissue of 61 patients with brain tumor,and control group(32).Results:Mean content of zinc:malignant brain tumor (94.90±18.39 μg/g)>benign brain tumor(83.30±20.52 μg/g)>normal brain tissue (51.44±13 64 μg/g);Mean content of copper:malignant brain tumor(28.76±11.65 μg/g)>benign brain tumor(18.25±7.13 μg/g)>normal brain tissue(11.25±5.19 μg/g).Conclusion:Our results indicate that trace element zinc and copper in tumor tissue are associated with malignant degree of brain tumor.Relative deficiency of copper content could be one of the cuase of tumor stroke.Deficiency of copper could aid in therapy for patients because it could inhibit growth of intracrania tumor.