大气污染与生殖发育关系研究的文献计量分析

Bibliometric analysis of associations between ambient pollution and reproductive and developmental health

目的 采用文献计量学方法,分析大气污染与生殖发育关系领域的主要研究特点和热点研究主题.方法 对1955-2013的PubMed及MEDLINE数据库中有关大气污染与生殖发育关系领域的英文研究论文的题录信息和其医学主题词（MeSH词）进行计量分析,计算标化词频.通过采用词频标准化和线性回归方法,对高频MeSH词分类分析得出该领域在大气污染物及成分、生殖发育健康终点和生物机制三方面的热点研究主题.结果 大气污染与生殖发育关系研究论文共2 315篇,52.9％（1 224篇）的研究时间为2004-2013年;人群研究占84.1％（1 947篇）,其中队列研究占10.9％（212篇）;美国学者发表论文占28.0％（647篇）,我国仅占2.3％（53篇）.大气污染物及成分研究方面,烟草污染、粉尘、一氧化碳和重金属主题词平均标化频次分别为46.96％、15.92％、5.03％和7.84％;生殖发育健康终点研究方面,流产、妊娠期暴露滞后效应和妊娠并发症主题词平均标化频次分别为4.36％、12.17％和6.01％;生物机制研究方面,母婴交换和DNA损伤主题词的平均标化频次分别为6.58％、1.31％.结论 大气污染物及成分研究的热点主题集中于烟草污染、粉尘、一氧化碳和重金属等方面;生殖发育健康终点研究的热点主题集中在流产、妊娠期暴露滞后效应和妊娠并发症方面;生物机制研究的热点主题集中在母婴交换和DNA损伤等方面.

Objective This study aims to evaluate the characteristics and the popular themes in the field of air pollution and reproductive and developmental health with the bibliometric approach. Method The articles from the year 1955 to 2013 in this field were retrieved by searching PubMed/MEDLINE using MeSH terms. The bibliographic information was analyzed to summarize the overall research characteristics. MeSH terms were sorted by their normalized frequency （NF） and classified into categories （air pollutants/ components, reproductive and developmental outcomes and biological mechanisms ） and then analyzed by regressive analysis to investigate the popular themes and their tendency. Results All 2 315 papers are retrieved in this field, and 52. 9% of the papers are published from the year 2004 to 2013. The 84. 1% of the studies are comlueted on the population, in which 10. 9% are cohort studies. The researchers from USA conduct 28.0% of the studies. Only 2. 3% of the studies are conducted by researchers from China. In the category of air pollutants/components, the high NF of MeSH terms, tobacco smoke pollutants, dust, carbon monoxide and heavy metals are 46.96% , 15.92% , 5.03% and 7.84% respectively. In the category of reproductive and developmental outcomes, the high NF of abortion, prenatal exposure delayed effects and pregnancy complications are 4. 36%, 12. 17% and 6. 01%. In the category of biological mechanisms, the high NF of maternal-fetal exchange and DNA damage are 6. 58% and 1.310/0. Conclusion Tobacco smoke pollutants, dust, carbon monoxide and heavy metals are the major concerns of air pollutants/components. Reproductive and developmental outcomes mainly focus on the abortion, prenatal exposure delayed effects and pregnancy complications. Maternal-fetal exchange and DNA damage are mostly concerned as the biological mechanisms.