胰岛素泵治疗初诊2型糖尿病的临床研究

Application of insulin pump in the treatment of newly diagnosed type 2 diabetes mellitus

目的观察胰岛素泵持续皮下输注(CSII)门冬胰岛素与门冬胰岛素30常规2次皮下注射对初诊2型糖尿病患者的治疗效果。方法将50例2型糖尿病患者随机分为两组,A组采用CSII治疗,持续皮下输注门冬胰岛素,B组于早、晚餐前注射门冬胰岛素30,比较治疗后两组空腹血糖、餐后2小时血糖、血糖达标时间、胰岛素用量、发生低血糖时血糖值。结果 CSII组和门冬胰岛素30常规2次皮下注射两组均可有效降低血糖(P<0.05),两组的空腹血糖在治疗后比较差异无统计学意义(P>0.05),但A组餐后2小时血糖好于B组(P<0.05)。CSII组发生低血糖时血糖值明显高于门冬胰岛素30常规2次皮下注射组(P<0.01)。结论在初诊2型糖尿病患者中短期应用胰岛素泵输注门冬胰岛素降糖效果优于门冬胰岛素30常规2次皮下注射,低血糖少,提高了患者的治疗依从性。

Objective To observe the therapeutic effect of treating newly diagnosed type 2 diabetes mellitus with aspart insulin continuous subcutaneous infusion and aspart insulin 30 subcutaneous injection. Methods 50 patients with type 2 DM were randomly divided into group A and group B,patients in group A were treated with aspart insulin continuous subcutaneous infusion. And patients in group B received aspart insulin 30 subcutaneous injection twice per day at morning and evening, and adjust drug dose according to the level of blood glucose. The levels of fasting plasma glucose （FPG）, 2 hours postprandial glucose （2h PG）, therapeutic time, insulin dose and the level of hypoglycemia were compared between the two groups. Results CSII and aspart 30 could decrease blood glucose efficiently （ P 〈 0. 01 ） , the differences of fasting plasma glucose （FPG） levels between the two groups was no statistically significant （P 〉 0. 05 ） , but 2 hours postprandial glucose （2h PG） in aspart CSII group was lower than that of aspart 30 group （ P 〈 0. 05 ）. It cost more time before hypoglycemia occurred in CSII group （P 〈 0. 01 ）. Conclusions Aspart insulin continuous subcutaneous infusion is effective and safe in the treatment of newly diagnosed type 2 diabetes mellitus.