摘要
目的 观察在吸入皮质激素的基础上联合茶碱控释剂或 β2 激动剂对慢性中度哮喘病人的治疗作用。方法 99例慢性中度哮喘病人随机分为吸入丙酸培氯松 +口服茶碱控释剂组 (T组 )和吸入丙酸培氯松加口服β2 激动剂组 (C组 ) ,疗程均为 8周。记录每日哮喘发作次数、症状评分和测定PEF ;治疗前和每治疗 2周后测定FVC、FEV1。结果 两组病人症状评分、发作次数以及肺功能在治疗后均出现明显改善 ,但两组间无明显差异。比较用药后第 4、6、8周PEF变异率较用药第 1周降低的差值 (△PEF)时 ,发现第 6和 8周T组△PEF明显大于C组。结论 在吸入皮质激素基础上 ,联合应用氨茶碱缓释剂或 β2 激动剂对慢性中度哮喘病人临床症状、肺功能均有明显改善作用。吸入皮质激素联合应用茶碱控释剂对PEF变异率降低幅度大于联合应用 β2 激动剂。
Objective\ To investigate the efficacy of combining corticosteroid inhalation with controlled-released theophylline or beta2-agonist to chronic moderate asthmatics.Method\ 99 chronic moderate asthmatics were divided randomly into two groups.Patients in treatment group were given inhaled becliomethnsone and oral controlled-released theophylline.Patients in controlled group were given inhaled becliomethnsone and oral beta2-agonist.Each course was 8 weeks.Frequency of asthma attack、clinic symptom score and peak expiratory flow(PEF)were taken everyday.FVC and FEF 1 were measured before treatment and every two weeks after treatment.Results\ Frequency of asthma attack、clinic symptom score and pulmonary function were improved significantly after treatment in both groups,but there was no difference in the above observed index between the two groups.The different value of the PEF(△PEF)between the first week and the sixth as well as eighth week in treatment group was higher than that in controlled group.Conclusion\ The treatment of inhaled corticosteroid combing with controlled-released theophylline or beta2-agonist can decrease frequencey of asthma attack,improve the clinic symptoms and the pulmonary function.Treatment of inhaled corticosteroid combining with controlled-released theophylline can decrease △PEF more significantly than that combing with beta2-agonist.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2001年第3期141-142,共2页
Chinese Journal of Practical Internal Medicine