摘要
目的探讨软骨凝集蛋白(Chondrolectin,CHODL)与C-myc在人非小细胞肺癌中的表达及其与临床病理特征之间的关系。方法采用免疫组织化学方法检测53例非小细胞肺癌石蜡标本以及43例癌旁对照组织标本,并进行相关分析。结果 CHODL主要分布在胞质与胞膜中,其在癌组织中的阳性表达率为79.25%,明显高于在癌旁组织中的表达(18.60%),C-myc在癌组织中的表达率为60.37%,明显高于其在癌旁组织中过度表达(30.23%),且差异均具有统计学意义;CHODL在癌组织中的表达与淋巴结转移有关,而与年龄、性别、组织分化、TNM分期、肿块大小均无关;C-myc在非小细胞肺癌组织中的表达与淋巴结转移、组织学分化、TNM分期有关(P<0.05),与年龄、性别、肿块大小无关(P>0.05),且差异具有统计学意义;CHODL与C-myc在肺癌组织中的表达呈正相关。结论 CHODL在肺癌组织中的作用可能与C-myc呈某种程度的相关性,并与肿瘤淋巴结转移相关,为CHODL在肿瘤转移方面打下基础。
Objective To explore the expression and clinical significance of chondrolectin and C-myc in hu-man non-small cell lung cancer and their clinical implication. Methods Immunohistochemical study was carried out to examine the expression of chondrolectin and C-myc and its association with clinicopathologic features in human non-small cell lung cancer. Results The positive rate for chondrolectin and C-myc expression in squamous tissues （79.25%and 60.73%） was significantly higher than those in non-tumor tissues （18.60%and 30.23%）;the positive ex-pression of chondrolectin was not correlated with the patient＆#39;s gender, age and histologic differentiation except that lymph node metastasis, the positive expression of C-myc was correlated with the patient＆#39;s lymph node metastasis, his-tologic differentiation and TNM stage, but without gender, age and size. In non-small cell lung cancer chondrolectin was positively correlated with C-myc. Conclusion Chondrolectin may be an important molecular marker in human non-small cell lung cancer.
出处
《海南医学》
CAS
2014年第9期1262-1265,共4页
Hainan Medical Journal
