摘要
目的:综述介绍泊沙康唑的药动和药效学评价。方法:检索10余年来的相关文献,介绍其药学相关信息。结果:泊沙康唑的口服制剂吸收在一定范围内与剂量相关,且明显受食物摄入的影响,相对生物利用度与给药方案相关,分次服用有助于提高其生物利用度(BA),主要通过葡萄糖醛酸转移酶(UDP)酶代谢,该酶的诱导或抑制剂会影响药物的浓度。结论:泊沙康唑是近年来新的三唑类抗真菌药,充分了解药品的药理、药动和药效学信息,有助于临床合理选药、用药。
Objective： To review the PK, PD, pharmacology, drug-drug interaction, safety and clinical application studies of posaconazole. Methods： Relevant information was identified through a literature search of Medline （1996-2013） and FDA website. Results： The oral absorption of Posaconazole is related with the dosage and significantly influenced by food. Multi-dose administration with Posaconazole wil improve the relative bioavailability. Posaconazole is mainly metabolized by UDP enzyme. The inducers and inhibitors of this enzyme wil affect the plasma concentration. Conclusion：Posaconazole is an extended -spectrum azole antifungal agents. The introduction of Posaconazole into China wil significantly expand both prophylaxis and treatment options for invasive fungal infections.
出处
《临床药物治疗杂志》
2014年第3期15-22,共8页
Clinical Medication Journal
关键词
泊沙康唑
药动学
药效学
药物相互作用
posaconazole
pharmacokinetics
pharmcodynamics
drug-drug interaction
