生酮饮食联合丙戊酸钠治疗癫痫患者的药学监护1例

Pharmaceutical Care of Ketogenic Diet Combined with Sodium Valproate in a Epileptic Patient

目的:分析生酮饮食联合丙戊酸钠引起的血氨升高的治疗方法。方法:临床药师参与1例使用丙戊酸钠患者,应用生酮饮食治疗癫痫,引起高血氨血症治疗过程,并对用药情况进行分析,提出用药干预措施。结果:给予更换抗癫痫药物,血氨由162μg·d L-1降至116μg·d L-1。结论:药师在整个治疗过程中,进行全面的药学监护,在药物剂量、药物服用方法以及药物不良反应方面均能发挥重要的作用。

Objective： To analyze the treatment strategies of hyperammonemia induced by ketogenic diet combined with sodium valproat. Methods： A epilepsy patient, who treated with sodium valproat, after she began the ketogenic diet, her venous ammonia level was elevated. The clinical pharmacist participated in the whole treatment process ,who analyse the reasons and give the possible treatment strategies. Results： Her venous ammonia level was fal en from 162μg·dL-1 to 116μg·dL-1 after we changed the antiepileptic drugs for her. Conclusion： The clinical pharmacist took the patient a great pharmaceutical care in the whole treatment process and played an important role in the terms of amount of drug dose, the way to take medicine and relevant adverse drug reaction.