同时性结直肠癌远处转移的相关临床病理因素分析

Correlation analysis of clinicopathological factors related with synchronous distant metastasis in colorectal cancer

目的探讨同时性结直肠癌远处转移的相关临床病理因素。方法收集2056例非连续性结直肠癌病例的临床病理资料,应用logistic回归进行单因素和多因素分析。结果单因素分析显示结直肠癌远处转移与性别、年龄等因素无关(P>0.05),与肿瘤部位、肿瘤大体类型、肿瘤最大径、组织类型、病理分级、T分期、N分期、术前CEA水平等因素有关(P<0.05);多因素分析显示肿瘤最大径、T分期、N分期、术前CEA水平是影响结直肠癌远处转移的独立因素(P<0.05)。结论结直肠癌远处转移与肿瘤最大径、T分期、N分期、术前CEA水平有关。

Objective To investigate the clinicopathological factors related with synchronous distant metastasis in colorectal cancer. Methods The clinicopathological data of 2056 non-consecutive patients with colorectal cancer was retrospectively analyzed. The associations between distant metastasis and clinicopathological factors were evaluated by Chi-square test and multiple logistic regression analysis. Results Univariate analysis showed that gender and age were not related with synchronous distant metastasis in colorectal cancer （ P 〉0.05）, and the tumor location, tumor gross type, tumor size, histological type, pathological grade, T stage, N stage, and preoperative CEA level were related with synchronous distant metastasis in colorectal cancer （ P 〈0.05）. Multivariate logistic regression analysis showed that tumor size, T stage, N stage, and preoperative CEA level were the independent factors of synchronous distant metastasis （ P 〈0.05）. Conclusion The synchronous distant in colorectal cancer is related with tumor size, T stage, N stage, and preoperative CEA level