糖尿病大鼠脑干听觉诱发电位和血一氧化氮含量的动态变化

Changes in brainstem auditory evoked potential and plasma nitric oxide in diabetic rats

目的 :探讨脑干听觉诱发电位 (BAEP)在早期诊断糖尿病中枢神经病变 (DCN)中的作用及血一氧化氮 (NO)与DCN发病的关系。方法 :采用在体糖尿病动物模型从成模开始动态观测BAEP变化 ,用硝酸还原酶法测血NO含量的动态变化。结果 :建模后 4周实验性糖尿病 (ED)组BAEPI、II、IV、V波PL和I-III、III-VIPL延长 (P <0 0 5 ) ,成模 6周后 ,ED组BAEP各波PL、IPL均出现明显延长 (P <0 0 1)。ED组血NO在成模 2周升到最高值 ,以后逐渐下降 ,与BAEP各PL、IPL变化呈负相关。结论 :BAEP是早期诊断DCN的客观灵敏指标 。

AIM: To investigate the role of brainstem auditory evoked potential(BAEP) in the early diagnosis of diabetic central neuropathy (DCN) and to probe into the relationship between plasma nitric oxide (NO) and DCN. METHODS: Experimental diabetes(ED) rat model was used. BAEP and plasma NO were measured dynamically after ED modeling. RESULTS: The peak latency (PL) of Ⅰ, Ⅲ, Ⅳ and V and the interpeak latency (IPL) of I-III and III-V of BAEP in ED group prolonged after 4 weeks of ED modeling (P<0 05). All PL and IPL of BAEP prolonged after 6 weeks?8 weeks and 10 weeks (P<0 01). The plasma NO increased to the top in ED group at 2 weeks and then decreased gradually. There was negative correlation between plasma NO and PL and IPL of BAEP. CONCLUSION: BAEP was sensitive and valuable in the early diagnosis of DCN. Reduction of plasma NO may play a role in the pathogenesis of DCN.