类风湿关节炎survivin,CD95及PTEN相关信号分子研究进展

Study on molecular mechanism of survivin,CD95,PTEN and other signal molecules in rheumatoid arthritis

类风湿关节炎是一种以关节滑膜浸润性增生、炎症反复发作及关节软骨和骨质破坏为主要病理改变的慢性自身免疫性疾病,凋亡抑制、过度增殖并侵袭关节软骨及骨质是类风湿关节炎的主要分子机制。本文对survivin、CD95、PTEN及其他基因的生物学特性,以及其对类风湿性关节炎病情进展和疾病调控中的作用进行综述。

Rheumatoid arthritis is a chronic autoimmune disease which characterized by the invasive hyperplasia of synoviai joints. Hyperproliferation of synovial membrane, recurrent inflammator, ar- ticular cartilage and bone destruction are the main characteristics. The apoptosis inhibition, hyperproliferation and invasion of articular cartilage and bone are the important molecular mechanisms of rheumatoid arthritis. This study make a summary for survivin, CD95, PTEN and other related gene biological characteristics, and the impact for the progression of rheumatoid arthritis.