硬膜外麻醉辅用曲马朵氟哌利多的临床观察

Clinical study on the effect of peridural anesthesia accessory with intravenous tramadol and droperdol mixture

目的了解曲马朵氟哌利多合剂辅助硬膜外麻醉的效果和 (SpO2 )改变。方法 75例妇科手术患者 (ASAⅠ～Ⅱ级 )随机分成三组 :①曲马朵组 (T组 ,n =2 5 )曲马朵 1.3mg·kg-1和氟哌利多 75 μg·kg-1;②哌替啶组(P组 ,n =2 5 ) ,哌替啶 1mg·kg-1和氟哌利多 75 μg·kg-1;③对照组 (N组 ,n =2 5 ) ,生理盐水 4ml,三组均为硬膜外麻醉成功后切皮前静注。观察三组患者的镇痛效果和用药前后SpO2 改变。结果T组无痛率 (88% )与P组 (92 % )比较 ,差异无显著意义 (P >0 .0 5 )。与对照组 (4 0 % )差异有显著性意义 (P <0 .0 5 )。T组各阶段SPO2 改变与用药前相比无显著差异 ,P组用药后 5、10、15min时与用药前比较 ,差异有显著性意义。结论曲马朵氟哌利多合剂辅助硬膜外麻醉效果确切 ,呼吸抑制发生率低 ,优于哌替啶。

Objective This study is to determine the effect of peridural anesthesia accessory with intravenous tramadol and droperdol mixture on analgesia and the SpO 2 level.Method 75 cases (ASA physical status Ⅰ～Ⅱ)of gynecological patients were randomly divided into three groups:(1)The tramadol group(T group,n=25),intravenous tramadol 1.3mg·kg -1 and droperdol 75μg·kg -1 ;(2)The pethidine group(P group,n=25),intravenous pethidine 1mg·kg -1 and droperdol 75μg·kg -1 ;(3)The control group(N group,n=25),intravenous injection was carried out after peridural anesthesia but before operation. The effects of analgesia and the changes of SpO 2 level before and after drugs were given were boserved among these three groups.Result The painless rate in T group was 88% and that in P group was 92%, however, that in control group was 40%.After statistical analysis, there was not significant difference between the T and P group ( P >0.05). The SpO 2 levels in different stages of T group had not changed in comparison with the SpO 2 level before drugs were given. The SpO 2 levels in different stages(5min,10min,15min after drugs were given) of P group had changed in comparison with the SpO 2 level before drugs were given, which had significant differences.Conclusion The effect of peridural anesthesia accessory with intravenous tramadol and droperdol mixture on analgesia is definite and its incidence of respiratory inhibition is very low, which is superior to petidine.