凝血酶治疗新生儿上消化道出血

Treatment of Neonate Upper Digestive Tract Bleeding with Thrombin-23 Cases Report

目的 观察凝血酶治疗新生儿上消化道出血疗效。方法 将 4 2例新生儿上消化道出血患儿随机分为治疗组 2 3例 ,对照组 19例 ,治疗组给予常规治疗加口服凝血酶治疗。对照组给予常规治疗 ,疗程 3d ,观察新生儿上消化道出血止血情况。结果 治疗组与对照组总有效率分别为 82 6 %、52 6 % ,经统计学检验 χ2=4 37,P <0 0 5,两组疗效有显著差异 ,治疗组优于对照组。症状改善时间治疗组平均 1 87± 0 51d ,对照组2 53± 0 54d ,经统计学检验t =0 89,P <0 0 5,两组治疗有显著差异 ,治疗组症状改善时间明显较对照组缩短。结论 凝血酶为治疗新生儿上消化道出血的一种有效药物。

Objective To observe the curative effect of treatment of neonate upper digestive tract bleeding (UDTB) with thrombin. Methods 42 cases of neonate UDTB were divided into treatment group (23 cases) and control group (19 cases) randomly. The patients in test group were treated with routine therapy and thrombin for 3 days. The patients in control group were treated with routine therapy for 3 days. Results The effective rates were 82.6% in treatment group and 52.6% in control group. There was significant difference between two groups in curative effect (P<0.05 χ 2=4.37) and in symptom improvement (P<0.05 t=0.89) and those in treatment group were better than in control group. Conclusion Thrombin might be an effective drug for treatment of neonate UDTB.